C6orf136
Uncharacterized protein C6orf136
Also known as: CF136_HUMAN, Em:AB023049.8
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5SQH8
- Gene
- C6orf136
- Ensembl
- ENSG00000204564
- Chromosome
- 6
- Canonical length
- 315 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
OverviewNCBI Gene
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
315 residues, UniProt reviewed canonical sequence.
>Q5SQH8|C6orf136
1 MYQPSRGAAR RLGPCLRAYQ ARPQDQLYPG TLPFPPLWPH STTTTSPSSP LFWSPLPPRL
61 PTQRLPQVPP LPLPQIQALS SAWVVLPPGK GEEGPGPELH SGCLDGLRSL FEGPPCPYPG
121 AWIPFQVPGT AHPSPATPSG DPSMEEHLSV MYERLRQELP KLFLQSHDYS LYSLDVEFIN
181 EILNIRTKGR TWYILSLTLC RFLAWNYFAH LRLEVLQLTR HPENWTLQAR WRLVGLPVHL
241 LFLRFYKRDK DEHYRTYDAY STFYLNSSGL ICRHRLDKLM PSHSPPTPVK KLLVGALVAL
301 GLSEPEPDLN LCSKPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C6orf136 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 54 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 54 nTPM
- skeletal muscle: 48 nTPM
- cerebellum: 46 nTPM
- cerebral cortex: 46 nTPM
- kidney: 40 nTPM
- colon: 38 nTPM
Single-cell type
- oocytes: 60 nCPM
- early primary spermatocytes: 41 nCPM
- enterocytes: 40 nCPM
- parietal cells: 30 nCPM
- brain excitatory neurons: 25 nCPM
- brain inhibitory neurons: 25 nCPM
Immune cell
- memory B-cell: 1.2 nTPM
- naive CD4 T-cell: 1.1 nTPM
- MAIT T-cell: 0.7 nTPM
- memory CD4 T-cell: 0.7 nTPM
- naive B-cell: 0.7 nTPM
- naive CD8 T-cell: 0.7 nTPM
Brain region
- cerebellum: 9.3 nTPM
- choroid plexus: 8 nTPM
- medulla oblongata: 7.8 nTPM
- cerebral cortex: 7.5 nTPM
- midbrain: 7.5 nTPM
- white matter: 7.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.35
- gnomAD pLI
- 0.95
- gnomAD missense Z
- 1.26
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF2358
- Uncharacterized conserved protein (DUF2358)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C6orf136 as an antibody target. Whether an autoantibody or antibody against C6orf136 could matter depends on whether native C6orf136 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C6orf136 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C6orf136 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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