Seroatlas · Human Serome Atlas

C6orf132

Uncharacterized protein C6orf132

Also known as: bA7K24.2, CF132_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T0Z8
Gene
C6orf132
Ensembl
ENSG00000188112
Chromosome
6
Canonical length
1188 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

No narrative summary is available for C6orf132 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1188 residues, UniProt reviewed canonical sequence.

>Q5T0Z8|C6orf132
     1  MKKKQTVQGT FSKLFGKKHT TTPSTSLYAT NPPWIFTQEA PEEGTGGFDG IYYGDNRFNT
    61  VSESGTATLK ARPRVRPLLT FLPLNAQENH GLAVPTPSVP DDFADKEVTG TSSLVNGNLR
   121  LYSSVGDLRP GQYGQDLLIP PPPPGPAPGP PQDISEPPGG SPLPSPPSTA PPPPPLLLEP
   181  PPPPSMAPPP PPVLEALSPP HTLSSPSIPT PPDFIPPAPP LAFLAPPPPP VPAPAPPAPA
   241  SPHTVGTRLF PPGGVTKWKS DVALNGRQAE ATRASPPRSP AEPKGSALGP NPEPHLTFPR
   301  SFKVPPPTPV RTSSIPVQEA QEAPRKEEGA TKKAPSRLPL PPSFHIRPAS QVYPDRAPEP
   361  DCPGELKATA PASPRLGQSQ SQADERAGTP PPAPPLPPPA PPLPPPAPPL PPAAPPLPCA
   421  QKAAHPPAGF TKTPKSSSPA LKPKPNPPSP ENTASSAPVD WRDPSQMEKL RNELAAYLCG
   481  SRREDRFLSH RPGPTVAPQS KEGKKGPRLP EKETLLSLPA KDTPPGVPEK SLGGSSLTET
   541  EAAPSLTLPS VDYIPQDSPT PSVRQIRNEL EARLSSAAEK EAKPSIGSLP PKPRLEGGRI
   601  CENGADDDKL SKPVAKNLPP QSTTLLPTTS LQPKAMLGPA IPPKATPEPA IPPKATLWPA
   661  TPPKATLGPA TPLKATSGPT TPLKATSGPA IASTATTLPT TTSQLMAEKD SGPAGQPEKP
   721  ASQEVSTPSQ ARGEGSPSEA TRLPTQGARS SAAFPPKTSP GGGEVPCLYK PHCHQSSLSR
   781  EVAVVMPTLA RGGAAGPGEP VEVKEPPGLP AKPPASAQPT DELLRHPVTG EVVERGSPMA
   841  LLLAARQRAQ KGRSVGAALG RSSLPGSLRD HSHQAEASSD SIFHSQGTPN SFTVVPKLPK
   901  EAEKDSPLTT EIPNKWGPRL GRDAEGTELS RRHNWTKPEP QAPVAWERVA PSNLPQGHPL
   961  PKSFSSPPSP SNKREEEEEE FNFEVIPPPP EFSNDPEPPA PALQYLGRQS SPPRNNYSDL
  1021  RQLPNAGPGA PPALGFSRFP AGARYAGAGG LERFSGGGRS LIKKRLYVGE PHRGPGLPHG
  1081  GTGRSLSSPN CFGPQPGGPE MRRVNSAGRA PPGGLHAPRL SLEGAARGAA EAKHKAPGSA
  1141  DYGFAPAAGR SPYTTTRYGS PINTFTVRPG TRHPISYVCS GAHRKATS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C6orf132 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
143 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 143 nTPM
  • skin: 66 nTPM
  • vagina: 48 nTPM
  • salivary gland: 41 nTPM
  • cervix: 40 nTPM
  • stomach: 32 nTPM

Single-cell type

  • esophageal apical cells: 2,337 nCPM
  • esophageal suprabasal cells: 493 nCPM
  • endometrial luminal cells: 449 nCPM
  • ocular epithelial cells: 442 nCPM
  • late spermatids: 307 nCPM
  • suprabasal keratinocytes: 281 nCPM

Immune cell

  • myeloid DC: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 1.4 nTPM
  • hippocampal formation: 1.4 nTPM
  • white matter: 1 nTPM
  • amygdala: 0.9 nTPM
  • basal ganglia: 0.9 nTPM
  • hypothalamus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
1.85
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C6orf132 as an antibody target. Whether an autoantibody or antibody against C6orf132 could matter depends on whether native C6orf132 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C6orf132 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C6orf132 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C6orf132. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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