Seroatlas · Human Serome Atlas

C6orf120

UPF0669 protein C6orf120

Also known as: bA160E12.4, CF120_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4R8
Gene: C6orf120
Ensembl: ENSG00000185127
Chromosome: 6
Canonical length: 191 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a conserved, N-glycosylated protein that likely functions in the cellular response to endoplasmic reticulum stress. This protein is able to induce apoptosis in vitro in CD4+ T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q7Z4R8|C6orf120
     1  MAAPRGRAAP WTTALLLLLA SQVLSPGSCA DEEEVPEEWV LLHVVQGQIG AGNYSYLRLN
    61  HEGKIVLRMR SLKGDADLYV SASSLHPSFD DYELQSATCG PDAVSIPAHF RRPVGIGVYG
   121  HPSHLESEFE MKVYYDGTVE QHPFGEAAYP ADGADAGQKH AGAPEDASQE EESVLWTILI
   181  SILKLVLEIL F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C6orf120 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

liver: 23 nTPM
retina: 22 nTPM
adipose tissue: 17 nTPM
adrenal gland: 16 nTPM
kidney: 15 nTPM
placenta: 15 nTPM

Single-cell type

late spermatids: 465 nCPM
early spermatids: 124 nCPM
epicardial cells: 105 nCPM
late primary spermatocytes: 81 nCPM
esophageal apical cells: 54 nCPM
extravillous trophoblasts: 42 nCPM

Immune cell

classical monocyte: 5.7 nTPM
basophil: 5.4 nTPM
intermediate monocyte: 5.4 nTPM
eosinophil: 5 nTPM
myeloid DC: 4.5 nTPM
naive CD4 T-cell: 4.5 nTPM

Brain region

white matter: 19 nTPM
thalamus: 17 nTPM
cerebral cortex: 17 nTPM
midbrain: 17 nTPM
spinal cord: 17 nTPM
cerebellum: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.01
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

UPF0669 protein C6orf120
Putative cytokine, C6ORF120

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C6orf120 as an antibody target. Whether an autoantibody or antibody against C6orf120 could matter depends on whether native C6orf120 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C6orf120 is annotated as secreted, so native C6orf120 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C6orf120 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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