Seroatlas · Human Serome Atlas

C6orf118

Uncharacterized protein C6orf118

Also known as: bA85G2.1, CF118_HUMAN, MGC23884

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T5N4
Gene: C6orf118
Ensembl: ENSG00000112539
Chromosome: 6
Canonical length: 469 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

No narrative summary is available for C6orf118 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q5T5N4|C6orf118
     1  MAEEREPELY LKWKHCETPG VKTLCNLKHC ETPGVKTLCN LKKLLNRLQK DHREDVYLYI
    61  SGHLNPNKLY QPPETILQHW PNAHRPKGER ASEVGEPPAG KVARMKEALA HFTIHTALVP
   121  SEAQDTPLFR YLNPQASLSH TSEEDFLPVE AVREGKEEKK GGPPGRGPPG WRRREELRLP
   181  DLKVLCYQEA GSRGTRDRHH YVSSYLAGAT SADRYRMFLR FQKEVLAKQD LLKNDFTGSK
   241  AAAGHERKLQ QELQKICTCS PQQFNRLHVF GKVFEDICNS SLIFGDLLKK VKDEYELYMA
   301  TLLESQPAAQ YEALLAQLKA LGQRPVKTAD MDLAREELRM LVTATKAALE QNDRLRSELE
   361  MEVALLQSAK ERSESSEKHI IDENRLTLTE KVEKKRCEIL SKWDEIQALE KEIKTTLVHT
   421  GISDITENRI KSIEHEAIQL ETENMILKKK IKGPLEIYQG ICKIRGNRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C6orf118 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 15 nTPM
choroid plexus: 9.4 nTPM
testis: 6.6 nTPM
lung: 1.9 nTPM
pituitary gland: 1.4 nTPM
basal ganglia: 1.3 nTPM

Single-cell type

ependymal cells: 334 nCPM
respiratory ciliated cells: 333 nCPM
fallopian tube ciliated cells: 314 nCPM
epididymal efferent duct ciliated cells: 237 nCPM
endometrial ciliated cells: 195 nCPM
choroid plexus epithelial cells: 131 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 62 nTPM
midbrain: 24 nTPM
medulla oblongata: 20 nTPM
spinal cord: 14 nTPM
pons: 8.9 nTPM
hippocampal formation: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -0.83
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C6orf118 as an antibody target. Whether an autoantibody or antibody against C6orf118 could matter depends on whether native C6orf118 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C6orf118 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C6orf118 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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