Seroatlas · Human Serome Atlas

C5orf58

Putative uncharacterized protein C5orf58

Also known as: CE058_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9J3I9
Gene
C5orf58
Ensembl
ENSG00000234511
Chromosome
5
Canonical length
81 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytokinetic bridge,Centriolar satellite,Cytosol

OverviewNCBI Gene

No narrative summary is available for C5orf58 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

81 residues, UniProt reviewed canonical sequence.

>C9J3I9|C5orf58
     1  MGKKRVTDHK LNVDKVIKNI NTISSELKKI KELSQLLLCD LILHFNHPIK TENLAEAERN
    61  NPLFEESKIS DVSLVSNSFS I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5orf58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
201 nTPM

Expression across tissuesHPA

Tissue

  • testis: 201 nTPM
  • bone marrow: 6.3 nTPM
  • lung: 4.5 nTPM
  • spleen: 3.3 nTPM
  • appendix: 2.6 nTPM
  • spinal cord: 2.3 nTPM

Single-cell type

  • early primary spermatocytes: 1,121 nCPM
  • late primary spermatocytes: 1,047 nCPM
  • oocytes: 309 nCPM
  • early spermatids: 88 nCPM
  • late spermatids: 69 nCPM
  • undifferentiated spermatogonia: 47 nCPM

Immune cell

  • naive CD8 T-cell: 1 nTPM
  • neutrophil: 1 nTPM
  • gdT-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • NK-cell: 0.6 nTPM
  • eosinophil: 0.5 nTPM

Brain region

  • cerebral cortex: 5.7 nTPM
  • white matter: 4.2 nTPM
  • pons: 3.2 nTPM
  • medulla oblongata: 3.1 nTPM
  • thalamus: 2.5 nTPM
  • midbrain: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0.05
gnomAD missense Z
0.4
DepMap mean gene effect
0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C5orf58 as an antibody target. Whether an autoantibody or antibody against C5orf58 could matter depends on whether native C5orf58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C5orf58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C5orf58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C5orf58. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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