C5orf52
Uncharacterized protein C5orf52
Also known as: CE052_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NGY3
- Gene
- C5orf52
- Ensembl
- ENSG00000187658
- Chromosome
- 5
- Canonical length
- 159 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for C5orf52 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
159 residues, UniProt reviewed canonical sequence.
>A6NGY3|C5orf52
1 MTQPTRPSVT CDQGSSTIGG TAAQATTSSS ATSGSNYQRD RLGRRPEIGV GGQPQICFPR
61 PRSAQQPVLF SLMNSSEAAM KKTLPKSHLS RVIIHDNRIT QRIYEMEVSA LEKTKKKISH
121 YYEHLKKKFM TEQLRKLGRW REESVNSNRY LTFGIPPPVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C5orf52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 36 nTPM
Expression across tissuesHPA
Tissue
- testis: 36 nTPM
- colon: 1.6 nTPM
- rectum: 1 nTPM
- duodenum: 0.6 nTPM
- fallopian tube: 0.6 nTPM
- small intestine: 0.6 nTPM
Single-cell type
- late spermatids: 3,321 nCPM
- early spermatids: 436 nCPM
- late primary spermatocytes: 148 nCPM
- colonocytes: 23 nCPM
- enteric stem cells: 13 nCPM
- enteric transient amplifying cells: 13 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 0.7 nTPM
- midbrain: 0.6 nTPM
- thalamus: 0.5 nTPM
- basal ganglia: 0.4 nTPM
- cerebral cortex: 0.4 nTPM
- medulla oblongata: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.54
- gnomAD pLI
- 0.06
- gnomAD missense Z
- 0.32
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Uncharacterized protein C5orf52
- Family of unknown function (DUF5528)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C5orf52 as an antibody target. Whether an autoantibody or antibody against C5orf52 could matter depends on whether native C5orf52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C5orf52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C5orf52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...