Seroatlas · Human Serome Atlas

C5orf47

Uncharacterized protein C5orf47

Also known as: CE047_HUMAN, LOC133491

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q569G3
Gene
C5orf47
Ensembl
ENSG00000185056
Chromosome
5
Canonical length
176 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C5orf47 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q569G3|C5orf47
     1  MAAAGRGREQ DSARFVYVTR FGSHQCSGVL QLGGRGAQGL WGQGPGAGCR QEKPREAMAV
    61  AGVQGGSELP LGSQLRVPTT PGVEAAASAS SQLRASRVQS GTRQSARAGL IQKDAAKKYD
   121  FPIPLNEASK IMKKKKKVLV WNRVYKVISR MLEENEKYRH RLKCQRLSSE SSNYTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5orf47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • midbrain: 0.1 nTPM

Single-cell type

  • early primary spermatocytes: 575 nCPM
  • late primary spermatocytes: 214 nCPM
  • differentiating spermatogonia: 102 nCPM
  • early spermatids: 100 nCPM
  • undifferentiated spermatogonia: 37 nCPM
  • oocytes: 28 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
0.46
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4680
  • Domain of unknown function (DUF4680)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C5orf47 as an antibody target. Whether an autoantibody or antibody against C5orf47 could matter depends on whether native C5orf47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C5orf47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C5orf47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C5orf47. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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