Seroatlas · Human Serome Atlas

C5orf46

Uncharacterized protein C5orf46

Also known as: AP-64, CE046_HUMAN, MGC23985, SSSP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWT4
Gene
C5orf46
Ensembl
ENSG00000178776
Chromosome
5
Canonical length
87 aa
Protein class
Predicted secreted proteins
Subcellular location
Nuclear speckles,Mitochondria
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>Q6UWT4|C5orf46
     1  MAVSVLRLTV VLGLLVLFLT CYADDKPDKP DDKPDDSGKD PKPDFPKFLS LLGTEIIENA
    61  VEFILRSMSR STGFMEFDDN EGKHSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5orf46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
171 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 171 nTPM
  • skin: 112 nTPM
  • blood vessel: 86 nTPM
  • testis: 18 nTPM
  • breast: 13 nTPM
  • heart muscle: 8.4 nTPM

Single-cell type

  • early spermatids: 429 nCPM
  • salivary acinar cells: 333 nCPM
  • late spermatids: 236 nCPM
  • salivary myoepithelial cells: 175 nCPM
  • late primary spermatocytes: 88 nCPM
  • lacrimal acinar cells: 70 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 4.8 nTPM
  • choroid plexus: 1.6 nTPM
  • pons: 0.5 nTPM
  • cerebral cortex: 0.3 nTPM
  • hippocampal formation: 0.3 nTPM
  • hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.47
gnomAD pLI
0.07
gnomAD missense Z
0.33
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4576
  • Domain of unknown function (DUF4576)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C5orf46 as an antibody target. Whether an autoantibody or antibody against C5orf46 could matter depends on whether native C5orf46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C5orf46 is annotated as secreted, so native C5orf46 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C5orf46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C5orf46. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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