Seroatlas · Human Serome Atlas

C5orf34

Uncharacterized protein C5orf34

Also known as: CE034_HUMAN, FLJ32363

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MH7
Gene: C5orf34
Ensembl: ENSG00000172244
Chromosome: 5
Canonical length: 638 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C5orf34 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>Q96MH7|C5orf34
     1  MAAELRMILY EDDSVQVQYV DGSTLQLSPC GSEFLFEKSP PVSAHPLEQP ERIRQRTHFV
    61  ISTYREQLQR ALDFRNSSAT CPFLSETIIP SERKKHIFID ITEVRWPSLD TDGTMIYMES
   121  GIVKITSLDG HAYLCLPRSQ HEFTVHFLCK VSQKSDSSAV LSETNNKAPK DKLVEKTGKI
   181  CIRGNLPGQR LKNKENEFHC QIMKSKETLK KMSCVNGTEG REELPSPGTK HTCVYTWVKQ
   241  CWSVAACPEE WKYPLSLALH FHNKISNMSK IDAHITQSRF LTSDISEERG KVVSVLPRAL
   301  SLSCPVPHLH RWNFCDSLLQ RQSDEYSYPE LVKMVWYKGV TYRLTHQNMN SIEIYSGDGS
   361  VFKSEGAYFG NYFTYYSIQE GSGKREEKTY SVNNLPPDRP GSPFTVGSLI KQATRILQHC
   421  VKMRLSLSHN YRICCWKMVP GINDSNILPL VLKESLIPSV GRFLAYSDDK VHAIFLDGIT
   481  LTLNWNFSSP IEKRQVNQGL NLGWCKLTFP DGQEQLIQIE HPEPYERYVT TVTSWCRRLT
   541  QTSPREMPTH SSSSVLQENW SVASELEKIQ KFNLLLENSG ILNQISNKKN EQQSFDHYKP
   601  GSSETLLGEV NENRVSIALK KTSEILHDID CLLSNSKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5orf34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

testis: 3.9 nTPM
thymus: 3.4 nTPM
lymph node: 2.6 nTPM
prostate: 2.2 nTPM
tonsil: 2.2 nTPM
breast: 1.5 nTPM

Single-cell type

adipocytes: 35 nCPM
early primary spermatocytes: 33 nCPM
decidual stromal cells: 30 nCPM
oocytes: 28 nCPM
pdcs: 26 nCPM
migrating cytotrophoblasts: 26 nCPM

Immune cell

plasmacytoid DC: 2.5 nTPM
naive CD8 T-cell: 1.4 nTPM
NK-cell: 0.9 nTPM
MAIT T-cell: 0.8 nTPM
memory B-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM

Brain region

cerebral cortex: 2.2 nTPM
medulla oblongata: 2.2 nTPM
spinal cord: 2.2 nTPM
pons: 2 nTPM
white matter: 2 nTPM
midbrain: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

C5orf34-like, N-terminal
C5orf34-like, C-terminal
C5orf34-like, second domain
C5orf34-like domain
C5orf34-like
C5orf34 C-terminal domain
C5orf34-like, N-terminal
C5orf34-like, second domain
Polo box domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C5orf34 as an antibody target. Whether an autoantibody or antibody against C5orf34 could matter depends on whether native C5orf34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C5orf34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C5orf34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...