Seroatlas · Human Serome Atlas

C5orf24

UPF0461 protein C5orf24

Also known as: CE024_HUMAN, FLJ37562

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z6I8
Gene
C5orf24
Ensembl
ENSG00000181904
Chromosome
5
Canonical length
188 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for C5orf24 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q7Z6I8|C5orf24
     1  MMHPVASSNP AFCGPGKPSC LNEDAMRAAD QFDIYSSQQS KYSHTVNHKP MVCQRQDPLN
    61  ETHLQTTSGR SIEIKDELKK KKNLNRSGKR GRPSGTTKSA GYRTSTGRPL GTTKAAGFKT
   121  SPGRPLGTTK AAGYKVSPGR PPGSIKALSR LADLGYGCGT AAFPYPMMHG RAVHGVEETS
   181  SEVKPPNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5orf24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • liver: 40 nTPM
  • kidney: 38 nTPM
  • cerebellum: 34 nTPM
  • blood vessel: 30 nTPM
  • thyroid gland: 28 nTPM
  • endometrium: 27 nTPM

Single-cell type

  • alveolar cells type 1: 101 nCPM
  • hepatocytes: 92 nCPM
  • vascular smooth muscle cells: 87 nCPM
  • thymic myoid cells: 84 nCPM
  • melanocytes: 84 nCPM
  • smooth muscle cells: 82 nCPM

Immune cell

  • plasmacytoid DC: 11 nTPM
  • eosinophil: 9.7 nTPM
  • classical monocyte: 9.1 nTPM
  • myeloid DC: 7.8 nTPM
  • naive CD4 T-cell: 7 nTPM
  • intermediate monocyte: 6.9 nTPM

Brain region

  • cerebellum: 53 nTPM
  • white matter: 45 nTPM
  • basal ganglia: 41 nTPM
  • spinal cord: 40 nTPM
  • cerebral cortex: 39 nTPM
  • medulla oblongata: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.73
gnomAD missense Z
0.95
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • DUF5568 family
  • Family of unknown function (DUF5568)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C5orf24 as an antibody target. Whether an autoantibody or antibody against C5orf24 could matter depends on whether native C5orf24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C5orf24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C5orf24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C5orf24. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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