Seroatlas · Human Serome Atlas

C5AR2

C5a anaphylatoxin chemotactic receptor 2

Also known as: C5AR2_HUMAN, C5L2, GPR77

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P296
Gene: C5AR2
Ensembl: ENSG00000134830
Chromosome: 19
Canonical length: 337 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q9P296|C5AR2
     1  MGNDSVSYEY GDYSDLSDRP VDCLDGACLA IDPLRVAPLP LYAAIFLVGV PGNAMVAWVA
    61  GKVARRRVGA TWLLHLAVAD LLCCLSLPIL AVPIARGGHW PYGAVGCRAL PSIILLTMYA
   121  SVLLLAALSA DLCFLALGPA WWSTVQRACG VQVACGAAWT LALLLTVPSA IYRRLHQEHF
   181  PARLQCVVDY GGSSSTENAV TAIRFLFGFL GPLVAVASCH SALLCWAARR CRPLGTAIVV
   241  GFFVCWAPYH LLGLVLTVAA PNSALLARAL RAEPLIVGLA LAHSCLNPML FLYFGRAQLR
   301  RSLPAACHWA LRESQGQDES VDSKKSTSHD LVSEMEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5AR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

spleen: 13 nTPM
lung: 6.1 nTPM
bone marrow: 5.5 nTPM
adipose tissue: 3.9 nTPM
appendix: 3.9 nTPM
tonsil: 3 nTPM

Single-cell type

neutrophils: 241 nCPM
kupffer cells: 150 nCPM
monocytes: 139 nCPM
macrophages: 84 nCPM
neutrophil progenitors: 56 nCPM
cdc: 35 nCPM

Immune cell

neutrophil: 33 nTPM
basophil: 18 nTPM
eosinophil: 12 nTPM
non-classical monocyte: 4.4 nTPM
classical monocyte: 2.7 nTPM
intermediate monocyte: 2.3 nTPM

Brain region

cerebral cortex: 11 nTPM
hippocampal formation: 9.2 nTPM
choroid plexus: 8 nTPM
medulla oblongata: 7 nTPM
white matter: 6.8 nTPM
cerebellum: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0.25
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C5AR2 as an antibody target. Whether an autoantibody or antibody against C5AR2 could matter depends on whether native C5AR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C5AR2 is annotated at the cell surface, where native C5AR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C5AR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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