Seroatlas · Human Serome Atlas

C4orf54

Uncharacterized protein C4orf54

Also known as: CD054_HUMAN, FOPV, LOC285556

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
D6RIA3
Gene
C4orf54
Ensembl
ENSG00000248713
Chromosome
4
Canonical length
1793 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear bodies,Cytosol

OverviewNCBI Gene

No narrative summary is available for C4orf54 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1793 residues, UniProt reviewed canonical sequence.

>D6RIA3|C4orf54
     1  MLSFHFWKSR GQPTDAASSV ADGIQTPRCC RRCQANNWTG QLSYRTLATV SAGAAAPQPQ
    61  TTSTASSRSL PTSLRLAAAP PQGLKNWEVV AAVAAVPTAL GPVQIRGTLL RATLQPLRGQ
   121  RRTQDFPSDH HCLFLSLKPG QGLIMEAAPP ELNSKARQAE VGDGVSSAQD SQELKQQLWP
   181  LPKPSASSQR EAKYVDMCAS AEVQRESPQT MKLTLGHCPG GQRASRSPKE KAQDEPSSKT
   241  PSPQNNPASS QLSRSQHSAS EEGGNFSSSS SSSPMNKAEE DGLSKMEDST TSTGALATSS
   301  SSLGFESESG ESEGCQAVGG EGEKISGGGG GGKGGGGGGA GDGTECRDII AKSQGSRDPP
   361  KVEEAHYITT HEIQLSEVEQ DMDFDVGLAS RWDFEDNNVI YSFVDYASFG GSDETPGDIT
   421  SLTEEDDDNS CYLSTTPSTN TTRTPSPTSS DLARPNAGRS GRDTSSTEVG SGPSDSGPTP
   481  PPTGPGTAPL TEPLPETPEA ASGAAAAAAS SCGSAASQIL LSIKPASRAI NEPSNVRAKQ
   541  NIIYAAKHEG DMSLRVSTAA EHNSSSLKQN PAAAVAQDHA KKFIAVPARL QTRCGAIRAK
   601  ELVDYSSGAS SAVSELDDAD KEVRNLTSRA FRSLAYPYFE ALNISSRESS TTLSEVGFGR
   661  WSTFLDLKCG GVGARVEQSL LRSSAASVAA GLRKGSGARA TADQLYIQSK KSQTKALEFV
   721  VSKVEGEIKH VETPLCFQKQ VQTGSRVVTL LEPLNVRSES KASSAPGPGR ATKGPGKGPG
   781  SAYTDDGSET SEGSKPTSRA DGPQKSKFAS SLLKNVISKK MQREHEFKME RGEVMDTSHH
   841  LSGTSKETEG ARGSERQRER GLQRQSSRHS EAGSEYTVVS MSDAGGEGSV AGSKSPVFKA
   901  STPRERNAGP GRNFTDGHTE VCEIKKSASE TVKGIFLRSQ NSAFRSWKEK EAEKREEQAP
   961  IGKLKLPKGG DWRADLGEIS ASKNTIMSRL FVPNIQQTPK DKQPRKQATK YPAAQATSTA
  1021  VIRPKAPEIK IRLGSVQQPS SDFNIAKLLT PKLAGGSASN LFKTIEDNSR AQQKLFRGDN
  1081  LEKVPHFQVR DIRDKSKAQG PLHQVRDVRK LIKGSGDSSD KGSVTPEQGL TGPKPRQLSA
  1141  AAGGSGSLSP MVITCQAVVN QREDSMDREP RESMGKGGGS RVLNSSSPEG TVLVHRASGR
  1201  LPVATIAPNK PEQGSYLPVL KIVSKASTQK TPEKLKEEEV KEEGKATKPA RNALEKLTAA
  1261  VRSMEELYSF NRNEWKRKSD PLPMMMDSHV LSLIASEERE GVVVADGDHD KLSKRLGEVE
  1321  ERGTGNKAGV VLRGAPIERL QRRNSNPSAE SVSARAAAFE NLARERPRSL YIPPVHKDVE
  1381  RTQPLQPLPP LPSNRNVFTV SASSIQKTGG VAGKFPQGPS PESPSAAKGI KSQGLRSLKI
  1441  SPATRAPPDE VTNRKSGSNL EKSNSDCENY LTIPLKGSSA AGELLSRPGA SREGPPNSSA
  1501  ATLCSLPPLS ARSQVPSSSK GSQVSGTSRP AWRTKPDNPR ETVAAPPGPQ SPEHPPTTIY
  1561  HQPPLPFTLQ GAQPQVLCFS PPSMPAPAPA ASAPVPTDPF QQAQPQQTQR KMLLDVTTGQ
  1621  YYLVDTPVQP MTRRLFDPET GQYVDVPMTS QQQAVAPMSI SVPPLALSPG AYGPTYMIYP
  1681  GFLPTVLPTN ALQPTPIARA PRGSELSPMV AEPSSKEAAA TFTEAPYFMA SGQSPASSTS
  1741  SAPAATSQLL GAKAFAQLHG KPVISITSQP LGPRIIAPPS FDGTTMSFVV EHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C4orf54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 66 nTPM
  • tongue: 13 nTPM
  • heart muscle: 5 nTPM
  • kidney: 0.8 nTPM
  • thymus: 0.7 nTPM
  • prostate: 0.4 nTPM

Single-cell type

  • myonuclei: 54 nCPM
  • endometrial ciliated cells: 22 nCPM
  • thymic myoid cells: 18 nCPM
  • epididymal efferent duct ciliated cells: 13 nCPM
  • renal collecting duct principal cells: 7.9 nCPM
  • cardiomyocytes: 7.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 2.2 nTPM
  • cerebral cortex: 1.4 nTPM
  • white matter: 0.5 nTPM
  • thalamus: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C4orf54 as an antibody target. Whether an autoantibody or antibody against C4orf54 could matter depends on whether native C4orf54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C4orf54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C4orf54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C4orf54. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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