Seroatlas · Human Serome Atlas

C4orf51

Uncharacterized protein C4orf51

Also known as: CD051_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9J302
Gene
C4orf51
Ensembl
ENSG00000237136
Chromosome
4
Canonical length
202 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C4orf51 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>C9J302|C4orf51
     1  MSHYFYLTPQ ILLPFSPLTS QEFDLIRRKA GASWQDETRW SDSSVTTYTG SYRKKQLDKS
    61  MCSQFSFRAG QHEPECKQMS LTNSSACHLL CWAGTQETTD IKGLFPDITR PFKKSFDVKH
   121  GVAHQIWDFG DCFPTPPNYG KYCVRPKKPA QEALINYSRR GKGVLKHLHG RCDSESKVCS
   181  SEDSEADRYS DYGWGGPSSP FN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C4orf51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
5.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 5.5 nTPM
  • epididymis: 0.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • early spermatids: 109 nCPM
  • late primary spermatocytes: 80 nCPM
  • cardiomyocytes: 71 nCPM
  • epicardial cells: 34 nCPM
  • adipocytes: 19 nCPM
  • thymocytes: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.2 nTPM
  • white matter: 0.2 nTPM
  • choroid plexus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
-0.25
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4722
  • Domain of unknown function (DUF4722)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C4orf51 as an antibody target. Whether an autoantibody or antibody against C4orf51 could matter depends on whether native C4orf51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C4orf51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C4orf51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C4orf51. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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