Seroatlas · Human Serome Atlas

C4orf50

Uncharacterized protein C4orf50

Also known as: CD050_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRC1
Gene: C4orf50
Canonical length: 1508 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C4orf50 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1508 residues, UniProt reviewed canonical sequence.

>Q6ZRC1|C4orf50
     1  MEPTAKGRTE ESFSYVIRAP SSEGFDIMNV DVKIDTSWIF QDMEDSAEER ECLQEEAAGR
    61  PDMDMGALRR QLESSEQKLS AAEDKYVTSE SGLRSRIQEL ELSERKLLRK VDQLSTHVAQ
   121  ERSAWLQAQE KLAALQGELA SQIREESVAR RQQWRLRRLQ ERLRRKDEAL GQQAAALERC
   181  RRTQRRQLGL VREQERVLRE QVQRLERNVR RLCRAAGLLL AQWDTAAPGS QGATEAAAEL
   241  RALQARAERS EREREEAARS LQEHRATERQ LRGQLEELRC CIYGLKLSEI GLQGQVEDLA
   301  QQNQCLREEL GAQAPIGHCS LDALGCVQGD SLPLPREEAL DPCRSQDWRN SLRSNDAPRQ
   361  RAPAGQSPEG PCTWSRIRPG RASSVLAPGP ETTSELPRDL AGSNREQLTL AEPSLDEQIL
   421  LLVCGCPPEE CLDESLLRMD LAWISENLAA DPAAEAFLLV QTSALPLWGP AGDSASWRPL
   481  LLQEVPSDGQ KIQEELATRS PPPPKATGHP GWDCHQTRGR GASLFHEAPY ISNHPFLKKH
   541  PKDLKDTWNN GGGSLAGRTE EGKARGTLGR KGKNLGDKYQ LSQESHQNLS LENGAGAAED
   601  VQDQNGASET KAATCRPGSW QEFLMPLLQG EASVSKEGPE SLSRRERVEG YVWGLRGGLS
   661  SENEEVAPPA TFSRAHETKE PWPTDSQLLA GKVRATGRTA RGKEENQVWL GNALLLQGGS
   721  LEDKGLEEED EMPHQEASGL GCRGAPEEPD SQEHESKEML FFAGETGLPL FPRFALSVEG
   781  AEPTDHGHPQ AVSKGHNRCA LTIDELAQDV EACFQQLSTL QPGSRGWQCS ASACRGENWS
   841  FAQKWHSGWE RAHSQQVWGN WGICSNEEAK SKESGEGDKP GKTTALGTSE VPGNPGTLPH
   901  WDEASPNPPQ GPAEPWGALE RVRSRFHQLI SGLKKQRSQI LHDNTKLHGD QERFHERVCA
   961  LEREREREVT KISRLERDNH RLVGDISQLK KELDQYLQAI SDLEDCNGKS YCKILELEEE
  1021  NETLKGNLGQ LQKATSESVR KSKDTMEQVT LENWKLQTLI SELGVSYKEL IKDIVLGIED
  1081  MIRALSGENE HLLRRVHVLE REVTLQRSTD QGRLVRGREH LQGKAKMHAL DKEVQVTPLT
  1141  GQLLSRACGP PLEEEMSLAA GQTGPSTGTG NSRRGADSPP PSLVWRNTGV ANALQGNVSG
  1201  AEVKEAHLEK EEKRPRCSVA QGQALSSLSN GPMLRDSEAE VTEEDPRLRA QQLHHRVLTL
  1261  QCQLRDQGAA HQASLDEATR LQEELQAKLE ELQKKQHEAK LAVTPLKAKI ASLVRKCRER
  1321  NRLITHLLQE LHRHGLGNLL LSELAQNMLN DVALAEYTAT FLAPGVPETS HHLDVKSEMT
  1381  AALRAQTYLL NPEMDSVLQS SLSSESWPIP EPEWPAQTAQ LDSLKLPLSL VSTLDPGTCL
  1441  AAVTVEPGLP AQRLQEKGGM PCPALQVDNV PAPSELLSPA RILAFHQELR QSICSNSQVH
  1501  KSPLELEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C4orf50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 0.7 nTPM
cerebral cortex: 0.7 nTPM
hippocampal formation: 0.2 nTPM
hypothalamus: 0.2 nTPM
thymus: 0.2 nTPM
amygdala: 0.1 nTPM

Single-cell type

brain inhibitory neurons: 63 nCPM
retinal ganglion cells: 46 nCPM
brain excitatory neurons: 43 nCPM
other brain neurons: 36 nCPM
adrenal medulla cells: 21 nCPM
müller glia: 19 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 20 nTPM
hippocampal formation: 15 nTPM
cerebral cortex: 15 nTPM
amygdala: 14 nTPM
white matter: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.12

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4527
Protein of unknown function (DUF4527)

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C4orf50 as an antibody target. Whether an autoantibody or antibody against C4orf50 could matter depends on whether native C4orf50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C4orf50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C4orf50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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