C4orf36
Uncharacterized protein C4orf36
Also known as: CD036_HUMAN, MGC26744
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96KX1
- Gene
- C4orf36
- Ensembl
- ENSG00000163633
- Chromosome
- 4
- Canonical length
- 117 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Focal adhesion sites,Cytosol
OverviewNCBI Gene
No narrative summary is available for C4orf36 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>Q96KX1|C4orf36
1 MAYGVPRKNT VKTILRGSCY NVQEPWDIAL LAKTWSTNLA NIKLPFLEEI SFGGSVQLTK
61 CTTIKDGLLP SAESIKLERE YEVKRLCKLK CQENTSKEIQ LLLRERPAGL RRPLPSKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C4orf36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 9.8 nTPM
Expression across tissuesHPA
Tissue
- testis: 9.8 nTPM
- skin: 1.3 nTPM
- cervix: 0.7 nTPM
- esophagus: 0.6 nTPM
- breast: 0.5 nTPM
- ovary: 0.5 nTPM
Single-cell type
- late spermatids: 123 nCPM
- early spermatids: 69 nCPM
- myonuclei: 5.5 nCPM
- respiratory ciliated cells: 4.2 nCPM
- myosatellite cells: 4 nCPM
- astrocytes: 3.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 1.2 nTPM
- hypothalamus: 1 nTPM
- pons: 1 nTPM
- thalamus: 1 nTPM
- amygdala: 0.9 nTPM
- basal ganglia: 0.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.01
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4522
- Protein of unknown function (DUF4522)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C4orf36 as an antibody target. Whether an autoantibody or antibody against C4orf36 could matter depends on whether native C4orf36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C4orf36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C4orf36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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