Seroatlas · Human Serome Atlas

C4orf33

UPF0462 protein C4orf33

Also known as: CD033_HUMAN, FLJ33703

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1A6
Gene: C4orf33
Ensembl: ENSG00000151470
Chromosome: 4
Canonical length: 199 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for C4orf33 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q8N1A6|C4orf33
     1  MDFKIEHTWD GFPVKHEPVF IRLNPGDRGV MMDISAPFFR DPPAPLGEPG KPFNELWDYE
    61  VVEAFFLNDI TEQYLEVELC PHGQHLVLLL SGRRNVWKQE LPLSFRMSRG ETKWEGKAYL
   121  PWSYFPPNVT KFNSFAIHGS KDKRSYEALY PVPQHELQQG QKPDFHCLEY FKSFNFNTLL
   181  GEEWKQPESD LWLIEKCDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C4orf33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

colon: 19 nTPM
duodenum: 16 nTPM
rectum: 16 nTPM
bone marrow: 15 nTPM
stomach: 15 nTPM
small intestine: 14 nTPM

Single-cell type

epicardial cells: 91 nCPM
megakaryocytes: 87 nCPM
cardiomyocytes: 56 nCPM
breast lactating cells: 52 nCPM
mast cells: 41 nCPM
endometrial ciliated cells: 40 nCPM

Immune cell

eosinophil: 30 nTPM
basophil: 19 nTPM
non-classical monocyte: 12 nTPM
myeloid DC: 12 nTPM
classical monocyte: 12 nTPM
intermediate monocyte: 12 nTPM

Brain region

cerebellum: 25 nTPM
pons: 15 nTPM
white matter: 15 nTPM
medulla oblongata: 14 nTPM
spinal cord: 14 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: -0.07
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

InteractionsUniProt · HPA

Protein binding partners of C4orf33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

VAC14

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C4orf33 as an antibody target. Whether an autoantibody or antibody against C4orf33 could matter depends on whether native C4orf33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C4orf33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C4orf33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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