C4orf17
Uncharacterized protein C4orf17
Also known as: CD017_HUMAN, DKFZP434G072
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q53FE4
- Gene
- C4orf17
- Ensembl
- ENSG00000138813
- Chromosome
- 4
- Canonical length
- 359 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mid piece
OverviewNCBI Gene
No narrative summary is available for C4orf17 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
359 residues, UniProt reviewed canonical sequence.
>Q53FE4|C4orf17
1 MNLNPPTSAL QIEGKGSHIM ARNVSCFLVR HTPHPRRVCH IKGLNNIPIC TVNDDENAFG
61 TLWGVGQSNY LEKNRIPFAN CSYPSSTAVQ ESPVRGMSPA PNGAKVPPRP HSEPSRKIKE
121 CFKTSSENPL VIKKEEIKAK RPPSPPKACS TPGSCSSGMT STKNDVKANT ICIPNYLDQE
181 IKILAKLCSI LHTDSLAEVL QWLLHATSKE KEWVSALIHS ELAEINLLTH HRRNTSMEPA
241 AETGKPPTVK SPPTVKLPPN FTAKSKVLTR DTEGDQPTRV SSQGSEENKE VPKEAEHKPP
301 LLIRRNNMKI PVAEYFSKPN SPPRPNTQES GSAKPVSARS IQEYNLCPQR ACYPSTHRRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C4orf17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- testis: 19 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late primary spermatocytes: 246 nCPM
- early spermatids: 159 nCPM
- late spermatids: 7.8 nCPM
- epicardial cells: 2.3 nCPM
- sertoli cells: 1.1 nCPM
- respiratory ciliated cells: 0.9 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.43
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.6
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C4orf17 as an antibody target. Whether an autoantibody or antibody against C4orf17 could matter depends on whether native C4orf17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C4orf17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C4orf17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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