Seroatlas · Human Serome Atlas

C3orf85

Uncharacterized protein C3orf85

Also known as: CC085_HUMAN, FLJ22763

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTC6
Gene
C3orf85
Ensembl
ENSG00000241224
Chromosome
3
Canonical length
90 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C3orf85 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>A0A1B0GTC6|C3orf85
     1  MAYKMLQVVL CSTLLIGALG APFLLEDPAN QFLRLKRHVN LQDYWDPDHS SDVWVNTLAK
    61  QARETWIALK TTAQYYLDMN TFTFDMSTAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C3orf85 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 66 nTPM
  • small intestine: 61 nTPM
  • liver: 19 nTPM
  • kidney: 13 nTPM
  • colon: 5 nTPM
  • rectum: 4.9 nTPM

Single-cell type

  • enterocytes: 940 nCPM
  • epididymal efferent duct absorptive cells: 126 nCPM
  • colonocytes: 105 nCPM
  • hepatocytes: 87 nCPM
  • paneth cells: 39 nCPM
  • proximal tubule cells: 37 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 3.2 nTPM
  • white matter: 3.2 nTPM
  • cerebellum: 3.1 nTPM
  • basal ganglia: 2.9 nTPM
  • medulla oblongata: 2.7 nTPM
  • amygdala: 2.6 nTPM

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C3orf85 as an antibody target. Whether an autoantibody or antibody against C3orf85 could matter depends on whether native C3orf85 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C3orf85 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C3orf85 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C3orf85. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...