Seroatlas · Human Serome Atlas

C3orf80

Uncharacterized membrane protein C3orf80

Also known as: CC080_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
F5H4A9
Gene
C3orf80
Ensembl
ENSG00000180044
Chromosome
3
Canonical length
247 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>F5H4A9|C3orf80
     1  MWGPGVTAEG LSVAPAPPPL LPLLLLLALA LVAPSRGGGG CAELACGERE RCCDATNATA
    61  VRCCKLPLHA FLDNVGWFVR KLSGLLILLV LFAIGYFLQR IICPSPRRYP RGQARPGQRP
   121  GPPGGAGPLG GAGPPDDDDD SPALLRDEAA AGSQDSLLDS GGGGRGRGGG GRSDPSCASE
   181  HEMRVVSPVF LQLPSYEEVK YLPTYEESMR LQQLSPGEVV LPVSVLGRPR GGVAAEPDGG
   241  EGRYPLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C3orf80 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 13 nTPM
  • colon: 7.2 nTPM
  • esophagus: 4.3 nTPM
  • cerebellum: 3.8 nTPM
  • amygdala: 3.3 nTPM
  • hippocampal formation: 2.4 nTPM

Single-cell type

  • esophageal apical cells: 46 nCPM
  • megakaryocytes: 31 nCPM
  • hematopoietic stem cells: 30 nCPM
  • late primary spermatocytes: 9.5 nCPM
  • megakaryocyte progenitors: 9.3 nCPM
  • parietal cells: 8.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • basal ganglia: 12 nTPM
  • white matter: 9.3 nTPM
  • cerebellum: 6 nTPM
  • hippocampal formation: 5 nTPM
  • amygdala: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0.19
gnomAD missense Z
0.4
DepMap mean gene effect
0.13
DepMap dependency class
none

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4719
  • Domain of unknown function (DUF4719)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C3orf80 as an antibody target. Whether an autoantibody or antibody against C3orf80 could matter depends on whether native C3orf80 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C3orf80 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C3orf80 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C3orf80. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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