C3orf70
UPF0524 protein C3orf70
Also known as: CC070_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NLC5
- Gene
- C3orf70
- Ensembl
- ENSG00000187068
- Chromosome
- 3
- Canonical length
- 250 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to be involved in circadian behavior and nervous system development. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
250 residues, UniProt reviewed canonical sequence.
>A6NLC5|C3orf70
1 MSAAASPASE RGWKSEKLDE AQALARSCAA RRPDFQPCDG LSICATHSHG KCFKLHWCCH
61 LGWCHCKYMY QPMTPVEQLP STEIPARPRE PTNTIQISVS LTEHFLKFAS VFQPPLPPDS
121 PRYCMISDLF IDNYQVKCIN GKMCYVQKQP APHSHRMSPE EVSAHDALIS KESNTPKIDH
181 CSSPSSSEDS GINAIGAHYV ESCDEDTEEG AELSSEEDYS PESSWEPDEC TLLSPSQSDL
241 EVIETIETTVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C3orf70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 14 nTPM
Expression across tissuesHPA
Tissue
- smooth muscle: 14 nTPM
- amygdala: 9.4 nTPM
- basal ganglia: 9.1 nTPM
- colon: 8.8 nTPM
- cerebral cortex: 8.7 nTPM
- seminal vesicle: 7.9 nTPM
Single-cell type
- oligodendrocyte progenitor cells: 206 nCPM
- retinal bipolar cells: 148 nCPM
- smooth muscle cells: 143 nCPM
- bergmann glia: 103 nCPM
- astrocytes: 82 nCPM
- sertoli cells: 81 nCPM
Immune cell
- basophil: 0.5 nTPM
- neutrophil: 0.4 nTPM
- eosinophil: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- memory B-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
Brain region
- medulla oblongata: 41 nTPM
- white matter: 36 nTPM
- spinal cord: 36 nTPM
- thalamus: 33 nTPM
- midbrain: 31 nTPM
- amygdala: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.59
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.08
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Protein domainsUniProt · Pfam · InterPro
- UPF0524 family
- UPF0524 of C3orf70
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C3orf70 as an antibody target. Whether an autoantibody or antibody against C3orf70 could matter depends on whether native C3orf70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C3orf70 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C3orf70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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