C3orf62
Uncharacterized protein C3orf62
Also known as: CC062_HUMAN, FLJ43654, MAPS
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZUJ4
- Gene
- C3orf62
- Ensembl
- ENSG00000188315
- Chromosome
- 3
- Canonical length
- 267 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles
OverviewNCBI Gene
Predicted to be involved in spermatogenesis. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
267 residues, UniProt reviewed canonical sequence.
>Q6ZUJ4|C3orf62
1 MHYIKTWSLL GEMSEKLRRC RKELTAAIDR AFEGVSYSQE CTGQQRLELS AAPLSFSLPV
61 HRLLCRRHPL AACSSAAPFA AVPCAPENEN PAFATNHAPV NAKPHALCPE RKPLTSKENV
121 LMHSSILAPE RESWRTAGEG ENWRKENLRK DMERDLKADS NMPLNNSSQE VTKDLLDMID
181 HTSIRTIEEL AGKIEFENEL NHMCGHCQDS PFKEEAWALL MDKSPQKATD ADPGSLKQAF
241 DDHNIVETVL DLEEDYNVMT SFKYQIELocalizationUniProt · AlphaFold · HPA
Whether an antibody against C3orf62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- testis: 17 nTPM
- spleen: 12 nTPM
- ovary: 12 nTPM
- adrenal gland: 11 nTPM
- cerebellum: 10 nTPM
- retina: 8.3 nTPM
Single-cell type
- neutrophils: 142 nCPM
- late primary spermatocytes: 97 nCPM
- adipocytes: 48 nCPM
- neutrophil progenitors: 35 nCPM
- early primary spermatocytes: 34 nCPM
- fibro-adipogenic progenitors: 30 nCPM
Immune cell
- neutrophil: 40 nTPM
- eosinophil: 5.3 nTPM
- classical monocyte: 5.1 nTPM
- plasmacytoid DC: 2.5 nTPM
- memory B-cell: 1.9 nTPM
- intermediate monocyte: 1.7 nTPM
Brain region
- choroid plexus: 18 nTPM
- thalamus: 14 nTPM
- cerebral cortex: 13 nTPM
- cerebellum: 13 nTPM
- pons: 12 nTPM
- white matter: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.37
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.17
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4712
- Domain of unknown function (DUF4712)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C3orf62 as an antibody target. Whether an autoantibody or antibody against C3orf62 could matter depends on whether native C3orf62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C3orf62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C3orf62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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