C3orf49
Putative uncharacterized protein C3orf49
Also known as: CC049_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96BT1
- Gene
- C3orf49
- Ensembl
- ENSG00000163632
- Chromosome
- 3
- Canonical length
- 292 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Centrosome,Cytosol
OverviewNCBI Gene
No narrative summary is available for C3orf49 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
292 residues, UniProt reviewed canonical sequence.
>Q96BT1|C3orf49
1 MAQPQLYLPE PFKIAYRKVG QCRRFQQLKK KNGSFKRKGI ERWHRAVSTN LLKQNVLVPK
61 EESSSDSDMG FHESQQNQKS NLKTKVKTAF GRMLSYKYRS KPACASQEGS TDHKEALLSN
121 TQSLLPRIVK EFSSPKLFTA KMRKLSENAT IQLDVVEAET EEITQGNTLL RARRTTKRLS
181 VTSLPSGLQK GPYSPKKRPH FPALKKKKRG MENILRKSDL TVGKLQMQVD DLIETVTDKS
241 MKLLAQRHAE LQQCEFLGDE ILQSSKQFQR ISKRTMRKYK LKNMTTKGPG DSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C3orf49 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 1.3 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 1.3 nTPM
- retina: 1.2 nTPM
- testis: 1.2 nTPM
- skeletal muscle: 1 nTPM
- skin: 0.8 nTPM
- esophagus: 0.7 nTPM
Single-cell type
- late spermatids: 50 nCPM
- cardiomyocytes: 43 nCPM
- myonuclei: 33 nCPM
- early spermatids: 28 nCPM
- adipocytes: 24 nCPM
- myosatellite cells: 17 nCPM
Immune cell
- NK-cell: 0.3 nTPM
- basophil: 0.2 nTPM
- naive CD4 T-cell: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
Brain region
- cerebral cortex: 18 nTPM
- cerebellum: 17 nTPM
- white matter: 17 nTPM
- basal ganglia: 14 nTPM
- hippocampal formation: 13 nTPM
- amygdala: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.47
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.11
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- C3orf49-like
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C3orf49 as an antibody target. Whether an autoantibody or antibody against C3orf49 could matter depends on whether native C3orf49 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C3orf49 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C3orf49 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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