Seroatlas · Human Serome Atlas

C3orf38

Uncharacterized protein C3orf38

Also known as: CC038_HUMAN, MGC26717

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JPI3
Gene: C3orf38
Ensembl: ENSG00000179021
Chromosome: 3
Canonical length: 329 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in positive regulation of apoptotic process. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q5JPI3|C3orf38
     1  MEMSGLSFSE MEGCRNLLGL LDNDEIMALC DTVTNRLVQP QDRQDAVHAI LAYSQSAEEL
    61  LRRRKVHREV IFKYLATQGI VIPPATEKHN LIQHAKDYWQ KQPQLKLKET PEPVTKTEDI
   121  HLFQQQVKED KKAEKVDFRR LGEEFCHWFF GLLNSQNPFL GPPQDEWGPQ HFWHDVKLRF
   181  YYNTSEQNVM DYHGAEIVSL RLLSLVKEEF LFLSPNLDSH GLKCASSPHG LVMVGVAGTV
   241  HRGNTCLGIF EQIFGLIRCP FVENTWKIKF INLKIMGESS LAPGTLPKPS VKFEQSDLEA
   301  FYNVITVCGT NEVRHNVKQA SDSGTGDQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C3orf38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 40 nTPM
testis: 31 nTPM
thymus: 20 nTPM
tonsil: 17 nTPM
lymph node: 17 nTPM
liver: 13 nTPM

Single-cell type

late spermatids: 500 nCPM
early spermatids: 307 nCPM
late primary spermatocytes: 289 nCPM
neutrophil progenitors: 86 nCPM
kupffer cells: 67 nCPM
esophageal apical cells: 55 nCPM

Immune cell

basophil: 48 nTPM
intermediate monocyte: 32 nTPM
non-classical monocyte: 28 nTPM
memory B-cell: 26 nTPM
eosinophil: 24 nTPM
myeloid DC: 24 nTPM

Brain region

white matter: 29 nTPM
cerebellum: 27 nTPM
cerebral cortex: 23 nTPM
basal ganglia: 22 nTPM
hypothalamus: 22 nTPM
spinal cord: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.34
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

NTF2-like domain superfamily
Uncharacterised protein C3orf38 (DUF4518)
Domain of unknown function (DUF4518)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C3orf38 as an antibody target. Whether an autoantibody or antibody against C3orf38 could matter depends on whether native C3orf38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C3orf38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C3orf38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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