Seroatlas · Human Serome Atlas

C3orf36

Uncharacterized protein C3orf36

Also known as: CC036_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3SXR2
Gene
C3orf36
Canonical length
165 aa

OverviewNCBI Gene

No narrative summary is available for C3orf36 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>Q3SXR2|C3orf36
     1  MQAETILEGL EAGLPQAVSS GLSLVPAPGL VLTCLSAPSG PGGMALEPPP TTLRKAFLAQ
    61  STLLESTLEG APEWAAPHPE EQRRSPPACS QHTPPLPSTP TGPPPCSPGG NHPLCALSGR
   121  GGGRCSIPSL SSSSTFSLFS SGCWNPRVKL RVRKSQSQGR AGQLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C3orf36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.13

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C3orf36 as an antibody target. Whether an autoantibody or antibody against C3orf36 could matter depends on whether native C3orf36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C3orf36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C3orf36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C3orf36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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