Seroatlas · Human Serome Atlas

C3orf22

Uncharacterized protein C3orf22

Also known as: CC022_HUMAN, MGC34728

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N5N4
Gene
C3orf22
Ensembl
ENSG00000180697
Chromosome
3
Canonical length
141 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>Q8N5N4|C3orf22
     1  MDSSACKKSH QSKKWRIQAQ ENFAKKFPYR LSWLTEPDPE PLQPWEVTND SNTVQLPLQK
    61  RLVPTRSIPV RGLGAPDFTS PSGSCPAPLP APSPPPLCNL WELKLLSRRF PRQLAFLLST
   121  RHTEAACPQT SKAAGLSRGL S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C3orf22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • testis: 48 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late spermatids: 3,096 nCPM
  • early spermatids: 406 nCPM
  • late primary spermatocytes: 101 nCPM
  • sertoli cells: 5.6 nCPM
  • undifferentiated spermatogonia: 4.3 nCPM
  • peritubular myoid cells: 3.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM
  • thalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0.1
gnomAD missense Z
-0.04
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein C3orf22

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C3orf22 as an antibody target. Whether an autoantibody or antibody against C3orf22 could matter depends on whether native C3orf22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C3orf22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C3orf22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C3orf22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...