Seroatlas · Human Serome Atlas

C2orf92

Uncharacterized protein C2orf92

Also known as: CB092_HUMAN, LINC01125

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVN3
Gene
C2orf92
Ensembl
ENSG00000228486
Chromosome
2
Canonical length
265 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>A0A1B0GVN3|C2orf92
     1  MSRAMALFFV LCWIQDEIVL QVFSKVPYDP SFDETRTAVR SITKRDTQKS YSQQKSLNNA
    61  AFASGSNERE EHLAKIFDEI LLQVFPKFPY DPSFNEATAV RSITKTDMRK GTSIAWNSPK
   121  PEYFLGSVDK IPDKDHLSEE KNFKESCLFD RDLREQLTTI DKETLQGAAK PDAHFRTMPC
   181  GQLLHFLQRN TIIAAVSGVA ILMAIVLLLL GLASYIRKKQ PSSPLANTTY NIFIMDGKTW
   241  WHNSEEKNFT KLAKKQKQLK SSSCV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf92 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 13 nTPM
  • testis: 11 nTPM
  • spinal cord: 3.6 nTPM
  • thyroid gland: 3.5 nTPM
  • spleen: 3.1 nTPM
  • liver: 2.7 nTPM

Single-cell type

  • early spermatids: 247 nCPM
  • late primary spermatocytes: 172 nCPM
  • late spermatids: 53 nCPM
  • fallopian tube ciliated cells: 38 nCPM
  • myonuclei: 36 nCPM
  • endometrial secretory cells: 36 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.9 nTPM
  • cerebellum: 1.8 nTPM
  • cerebral cortex: 1.6 nTPM
  • midbrain: 1.3 nTPM
  • pons: 1.3 nTPM
  • medulla oblongata: 1.2 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf92 as an antibody target. Whether an autoantibody or antibody against C2orf92 could matter depends on whether native C2orf92 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf92 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2orf92 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C2orf92. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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