Seroatlas · Human Serome Atlas

C2orf88

Small membrane A-kinase anchor protein

Also known as: MGC13057, SMAKA_HUMAN, smAKAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSF0
Gene
C2orf88
Ensembl
ENSG00000187699
Chromosome
2
Canonical length
95 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>Q9BSF0|C2orf88
     1  MGCMKSKQTF PFPTIYEGEK QHESEEPFMP EERCLPRMAS PVNVKEEVKE PPGTNTVILE
    61  YAHRLSQDIL CDALQQWACN NIKYHDIPYI ESEGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf88 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • testis: 69 nTPM
  • cervix: 45 nTPM
  • small intestine: 42 nTPM
  • rectum: 36 nTPM
  • colon: 34 nTPM
  • parathyroid gland: 33 nTPM

Single-cell type

  • platelets: 1,847 nCPM
  • late spermatids: 1,845 nCPM
  • early spermatids: 1,540 nCPM
  • megakaryocytes: 538 nCPM
  • enterocytes: 443 nCPM
  • epicardial cells: 382 nCPM

Immune cell

  • total PBMC: 17 nTPM
  • neutrophil: 7.3 nTPM
  • plasmacytoid DC: 3 nTPM
  • naive B-cell: 2.9 nTPM
  • memory B-cell: 2.7 nTPM
  • eosinophil: 0.9 nTPM

Brain region

  • white matter: 56 nTPM
  • midbrain: 41 nTPM
  • spinal cord: 41 nTPM
  • hypothalamus: 41 nTPM
  • basal ganglia: 40 nTPM
  • medulla oblongata: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
gnomAD missense Z
-0.01
DepMap mean gene effect
0.01
DepMap dependency class
none

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small membrane A-kinase anchor protein
  • Small membrane A-kinase anchor protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf88 as an antibody target. Whether an autoantibody or antibody against C2orf88 could matter depends on whether native C2orf88 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf88 is annotated at the cell surface, where native C2orf88 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C2orf88 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C2orf88. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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