C2orf80
Uncharacterized protein C2orf80
Also known as: CB080_HUMAN, GONDA1, LOC389073
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q0P641
- Gene
- C2orf80
- Ensembl
- ENSG00000188674
- Chromosome
- 2
- Canonical length
- 193 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus
OverviewNCBI Gene
No narrative summary is available for C2orf80 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
193 residues, UniProt reviewed canonical sequence.
>Q0P641|C2orf80
1 MERRLIKKEM KKLLGDYIGI RLRENEFDPK GRRQLTFLDD MAHYDLAISV ALQWLDPSED
61 LTWLEWEELK IPLHGRPIYP NRREREAMIL SSYAGILMNS IPIEEVFKIY GADSSADSGT
121 IKVPRVSSLC LSLHPFAMLT APKAAAYARK QSVKSRKVTT NKNATSISAK EANATEWKSS
181 QRFSDTQPKH KVTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C2orf80 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 40 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 40 nTPM
- amygdala: 36 nTPM
- basal ganglia: 35 nTPM
- hippocampal formation: 26 nTPM
- hypothalamus: 25 nTPM
- midbrain: 13 nTPM
Single-cell type
- oligodendrocyte progenitor cells: 45 nCPM
- other brain neurons: 31 nCPM
- brain inhibitory neurons: 30 nCPM
- brain excitatory neurons: 29 nCPM
- breast lactating cells: 10 nCPM
- bergmann glia: 4.4 nCPM
Immune cell
- neutrophil: 4.2 nTPM
- basophil: 2.3 nTPM
- plasmacytoid DC: 0.8 nTPM
- classical monocyte: 0.6 nTPM
- naive B-cell: 0.6 nTPM
- eosinophil: 0.4 nTPM
Brain region
- cerebral cortex: 48 nTPM
- basal ganglia: 47 nTPM
- hypothalamus: 34 nTPM
- hippocampal formation: 33 nTPM
- amygdala: 29 nTPM
- white matter: 23 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.63
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.1
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Uncharacterized protein C2orf80
- Family of unknown function (DUF5563)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C2orf80 as an antibody target. Whether an autoantibody or antibody against C2orf80 could matter depends on whether native C2orf80 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C2orf80 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C2orf80 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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