Seroatlas · Human Serome Atlas

C2orf78

Uncharacterized protein C2orf78

Also known as: CB078_HUMAN, COG5373, FLJ43987, hCG1989538

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCI8
Gene: C2orf78
Ensembl: ENSG00000187833
Chromosome: 2
Canonical length: 922 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for C2orf78 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

922 residues, UniProt reviewed canonical sequence.

>A6NCI8|C2orf78
     1  MHWLASATQT SASIVSSSLL SAVDVSSSLT MSEYFQNTSL PGTANSRQFS LPVVSNAAFL
    61  TGSISNFSRA SAPAISSAWL QPSASGTSFQ PLMGSAYLYQ HSSTTMLSGV TGQSHICTSA
   121  ASYPGVFEWD STASTVKKSS SLRDFTVTVI DQNTAVSSMS MTAQYYKTSD TNTMVPLYPS
   181  LSASLVQGTL TQIPNQQGHN LSLPCQIGSQ VYYYNQGTLG PQLSCLQSYG SVSYTGYRAS
   241  AHQPEMVMVL KEVQPTNVLP PVSTSGMYYS VSSQPITETS VQVMETSLGM DTSLGLQSPS
   301  QTFCLPQTPE FSKSFSSRNT QTLESNPSPE LGDISITPVQ SPTNLLTLSP APSQEKNENE
   361  NLDEIKTNLS KPLDVHQILI GNQDPPLLPV EIPDIHPLLA CIDPLGQEEQ PGSENANLRN
   421  KSLSLEDQGI FENGIESSSD LADITTWVED TYLPPIFSSL QDLDQPESPS AKKAKDTSAI
   481  KVNQVQEKSC VIKGHSDQVR KNKHKASEPI QGAPKAKIQP KNPECLLERE VVVGSATVSN
   541  SASVNKAKHS SNKPHKAASS RISKTKSHGQ EKTKGNRKNS SKKSEESKQS GKKVKVEEKQ
   601  TIPNMKRKKN QPELSQKTLK KPRSSLGMHM LESVQVFHAL GKKIDMKTGF SSSRTLGSSS
   661  NTQNRQPFPA LKPWLDIQHE GKGPEKIQVK AQKLDGSAEK ECTSPSHSEL PPPGKVKLIP
   721  LPFLTLDQPQ ARHVSRRPNP LASRRPAVAY PARPDSTNSA QSNAVNPSRP APTNTSLTGP
   781  ATPAQPISAK ATQPSSANPT QPTVPQSAAS RPSAYKTSSC SSLQREPVST AVTSLRSLPK
   841  PQNQFLIQDF SLQPRPWRKP TVPEPVMSTP ITEEQRPERE AMKRKAQQER ENAAKYTSLG
   901  KVQFFIERER DMEIAEYYGY TI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf78 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 59 nCPM
late primary spermatocytes: 44 nCPM
late spermatids: 8.6 nCPM
esophageal apical cells: 4 nCPM
sertoli cells: 1.2 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Domain of unknown function DUF4629
Uncharacterized protein C2orf78-like
Domain of unknown function (DUF4629)

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf78 as an antibody target. Whether an autoantibody or antibody against C2orf78 could matter depends on whether native C2orf78 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf78 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2orf78 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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