Seroatlas · Human Serome Atlas

C2orf76

UPF0538 protein C2orf76

Also known as: AIM29, CB076_HUMAN, LOC130355, MGC104437

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3KRA6
Gene
C2orf76
Ensembl
ENSG00000186132
Chromosome
2
Canonical length
126 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

No narrative summary is available for C2orf76 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>Q3KRA6|C2orf76
     1  MAPGEVTITV RLIRSFEHRN FKPVVYHGVN LDQTVKEFIV FLKQDIPLRT NLPPPFRNYK
    61  YDALKIIHQA HKSKTNELVL SLEDDERLLL KEDSTLKAAG IASETEIAFF CEEDYKNYKA
   121  NPISSW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf76 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 41 nTPM
  • spinal cord: 24 nTPM
  • breast: 21 nTPM
  • midbrain: 20 nTPM
  • skin: 19 nTPM
  • fallopian tube: 19 nTPM

Single-cell type

  • oocytes: 175 nCPM
  • megakaryocytes: 80 nCPM
  • late primary spermatocytes: 68 nCPM
  • parietal cells: 65 nCPM
  • esophageal apical cells: 56 nCPM
  • epididymal principal cells: 53 nCPM

Immune cell

  • neutrophil: 38 nTPM
  • NK-cell: 33 nTPM
  • basophil: 29 nTPM
  • eosinophil: 22 nTPM
  • myeloid DC: 21 nTPM
  • classical monocyte: 21 nTPM

Brain region

  • white matter: 19 nTPM
  • medulla oblongata: 15 nTPM
  • spinal cord: 14 nTPM
  • cerebellum: 13 nTPM
  • pons: 13 nTPM
  • hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.47
gnomAD pLI
0.01
gnomAD missense Z
0.21
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterised protein family UPF0538
  • Uncharacterized conserved protein (DUF2340)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf76 as an antibody target. Whether an autoantibody or antibody against C2orf76 could matter depends on whether native C2orf76 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf76 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2orf76 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C2orf76. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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