Seroatlas · Human Serome Atlas

C2orf74

Uncharacterized protein C2orf74

Also known as: CB074_HUMAN, LOC339804

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MZ97
Gene
C2orf74
Ensembl
ENSG00000237651
Chromosome
2
Canonical length
187 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Centrosome

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>A8MZ97|C2orf74
     1  MSFETTAITF FIILLICLIC ILLLLVVFLY KCFQGRKGKE TKKVPCTDAN GGVDCAAAKV
    61  VTSNPEDHER ILMQVMNLNV PMRPGILVQR QSKEVLATPL ENRRDMEAEE ENQINEKQEP
   121  ENAGETGQEE DDGLQKIHTS VTRTPSVVES QKRPLKGVTF SREVIVVDLG NEYPTPRSYT
   181  REHKERK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf74 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 74 nTPM
  • basal ganglia: 71 nTPM
  • midbrain: 68 nTPM
  • cerebral cortex: 68 nTPM
  • hypothalamus: 65 nTPM
  • spinal cord: 63 nTPM

Single-cell type

  • other brain neurons: 26 nCPM
  • brain excitatory neurons: 21 nCPM
  • brain inhibitory neurons: 20 nCPM
  • oligodendrocytes: 20 nCPM
  • early spermatids: 20 nCPM
  • microglia: 18 nCPM

Immune cell

  • memory B-cell: 32 nTPM
  • NK-cell: 30 nTPM
  • naive CD4 T-cell: 30 nTPM
  • eosinophil: 28 nTPM
  • T-reg: 26 nTPM
  • naive CD8 T-cell: 24 nTPM

Brain region

  • hypothalamus: 35 nTPM
  • cerebral cortex: 35 nTPM
  • midbrain: 34 nTPM
  • thalamus: 32 nTPM
  • pons: 31 nTPM
  • basal ganglia: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0.13
gnomAD missense Z
0.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4642
  • Domain of unknown function (DUF4642)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf74 as an antibody target. Whether an autoantibody or antibody against C2orf74 could matter depends on whether native C2orf74 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf74 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2orf74 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C2orf74. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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