Seroatlas · Human Serome Atlas

C2orf68

UPF0561 protein C2orf68

Also known as: CB068_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2NKX9
Gene
C2orf68
Ensembl
ENSG00000168887
Chromosome
2
Canonical length
166 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Nucleoli,Mitochondria

OverviewNCBI Gene

No narrative summary is available for C2orf68 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>Q2NKX9|C2orf68
     1  MEAGPHPRPG HCCKPGGRLD MNHGFVHHIR RNQIARDDYD KKVKQAAKEK VRRRHTPAPT
    61  RPRKPDLQVY LPRHRDVSAH PRNPDYEESG ESSSSGGSEL EPSGHQLFCL EYEADSGEVT
   121  SVIVYQGDDP GKVSEKVSAH TPLDPPMREA LKLRIQEEIA KRQSQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 21 nTPM
  • skeletal muscle: 20 nTPM
  • cervix: 19 nTPM
  • retina: 19 nTPM
  • cerebellum: 17 nTPM
  • spleen: 17 nTPM

Single-cell type

  • platelets: 75 nCPM
  • cytotrophoblasts: 62 nCPM
  • esophageal apical cells: 53 nCPM
  • parietal cells: 46 nCPM
  • cholangiocytes: 45 nCPM
  • migrating cytotrophoblasts: 42 nCPM

Immune cell

  • eosinophil: 59 nTPM
  • neutrophil: 49 nTPM
  • basophil: 33 nTPM
  • NK-cell: 31 nTPM
  • naive CD4 T-cell: 31 nTPM
  • classical monocyte: 30 nTPM

Brain region

  • cerebellum: 33 nTPM
  • white matter: 32 nTPM
  • medulla oblongata: 26 nTPM
  • basal ganglia: 25 nTPM
  • choroid plexus: 24 nTPM
  • midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.71
gnomAD pLI
0
gnomAD missense Z
-0.46
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterised protein family UPF0561
  • Uncharacterised protein family UPF0561

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf68 as an antibody target. Whether an autoantibody or antibody against C2orf68 could matter depends on whether native C2orf68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf68 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2orf68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C2orf68. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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