Seroatlas · Human Serome Atlas

C2orf66

Uncharacterized protein C2orf66

Also known as: CB066_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXQ4
Gene
C2orf66
Canonical length
117 aa
Protein class
Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for C2orf66 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>Q6UXQ4|C2orf66
     1  MIIDSSRIPS FTQLHSTMTR APLLLLCVAL VLLGHVNGAT VRNEDKWKPL NNPRNRDLFF
    61  RRLQAYFKGR GLDLGTFPNP FPTNENPRPL SFQSELTASA SADYEEQKNS FHNYLKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf66 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
9.8 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 9.8 nTPM
  • pituitary gland: 7.3 nTPM
  • hypothalamus: 4.7 nTPM
  • adipose tissue: 3.1 nTPM
  • testis: 2.8 nTPM
  • retina: 1.7 nTPM

Single-cell type

  • early spermatids: 58 nCPM
  • late primary spermatocytes: 9.5 nCPM
  • other brain neurons: 9 nCPM
  • corticotrophs: 8.7 nCPM
  • lactotrophs: 6.3 nCPM
  • gonadotrophs: 5.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 8.4 nTPM
  • hypothalamus: 6.7 nTPM
  • pons: 3.7 nTPM
  • medulla oblongata: 2.5 nTPM
  • amygdala: 2 nTPM
  • basal ganglia: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.01
gnomAD missense Z
0.28
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4720
  • Domain of unknown function (DUF4720)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf66 as an antibody target. Whether an autoantibody or antibody against C2orf66 could matter depends on whether native C2orf66 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf66 is annotated as secreted, so native C2orf66 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C2orf66 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C2orf66. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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