Seroatlas · Human Serome Atlas

C2orf42

Uncharacterized protein C2orf42

Also known as: CB042_HUMAN, FLJ20558

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWW7
Gene: C2orf42
Ensembl: ENSG00000115998
Chromosome: 2
Canonical length: 574 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>Q9NWW7|C2orf42
     1  MEPNSLRTKV PAFLSDLGKA TLRGIRKCPR CGTYNGTRGL SCKNKTCGTI FRYGARKQPS
    61  VEAVKIITGS DLQVYSVRQR DRGPDYRCFV ELGVSETTIQ TVDGTIITQL SSGRCYVPSC
   121  LKAATQGVVE NQCQHIKLAV NCQAEATPLT LKSSVLNAMQ ASPETKQTIW QLATEPTGPL
   181  VQRITKNILV VKCKASQKHS LGYLHTSFVQ KVSGKSLPER RFFCSCQTLK SHKSNASKDE
   241  TAQRCIHFFA CICAFASDET LAQEFSDFLN FDSSGLKEII VPQLGCHSES TVSACESTAS
   301  KSKKRRKDEV SGAQMNSSLL PQDAVSSNLR KSGLKKPVVA SSLKRQACGQ LLDEAQVTLS
   361  FQDWLASVTE RIHQTMHYQF DGKPEPLVFH IPQSFFDALQ QRISIGSAKK RLPNSTTAFV
   421  RKDALPLGTF SKYTWHITNI LQVKQILDTP EMPLEITRSF IQNRDGTYEL FKCPKVEVES
   481  IAETYGRIEK QPVLRPLELK TFLKVGNTSP DQKEPTPFII EWIPDILPQS KIGELRIKFE
   541  YGHHRNGHVA EYQDQRPPLD QPLELAPLTT ITFP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
liver: 14 nTPM
lymph node: 12 nTPM
cerebellum: 11 nTPM
tonsil: 11 nTPM
parathyroid gland: 11 nTPM

Single-cell type

early spermatids: 263 nCPM
late primary spermatocytes: 217 nCPM
late spermatids: 142 nCPM
early primary spermatocytes: 54 nCPM
thymocytes: 32 nCPM
myonuclei: 28 nCPM

Immune cell

NK-cell: 22 nTPM
MAIT T-cell: 16 nTPM
T-reg: 16 nTPM
naive CD8 T-cell: 15 nTPM
memory CD8 T-cell: 15 nTPM
memory B-cell: 14 nTPM

Brain region

cerebellum: 29 nTPM
white matter: 28 nTPM
basal ganglia: 21 nTPM
thalamus: 21 nTPM
hypothalamus: 20 nTPM
midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.01
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Uncharacterised protein C2orf42
Putative treble-clef, zinc-finger domain
Putative treble-clef, zinc-finger, Zn-binding

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf42 as an antibody target. Whether an autoantibody or antibody against C2orf42 could matter depends on whether native C2orf42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2orf42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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