Seroatlas · Human Serome Atlas

C2orf15

Uncharacterized protein C2orf15

Also known as: CB015_HUMAN, MGC29762

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WU43
Gene
C2orf15
Ensembl
ENSG00000273045
Chromosome
2
Canonical length
91 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

91 residues, UniProt reviewed canonical sequence.

>Q8WU43|C2orf15
     1  MGFSLSKSAT QVSAIHMDSK VDDHLIRGTE KSRLEPATQL FQNTKKIRLE DTNQENFTRI
    61  EGTGTGSLSG KALGSVVYVK ESDGLEMTDV E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2orf15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
5.9 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 5.9 nTPM
  • thyroid gland: 5.8 nTPM
  • parathyroid gland: 5.7 nTPM
  • epididymis: 5.6 nTPM
  • kidney: 5 nTPM
  • duodenum: 3.8 nTPM

Single-cell type

  • paneth cells: 3.9 nCPM
  • epididymal efferent duct ciliated cells: 2.1 nCPM
  • corticotrophs: 2 nCPM
  • prostatic club cells: 1.8 nCPM
  • mucous neck cells: 1.6 nCPM
  • epididymal efferent duct absorptive cells: 1.5 nCPM

Immune cell

  • MAIT T-cell: 4.7 nTPM
  • naive CD4 T-cell: 4.3 nTPM
  • NK-cell: 3.8 nTPM
  • memory CD4 T-cell: 3.2 nTPM
  • memory CD8 T-cell: 2.5 nTPM
  • naive CD8 T-cell: 2.2 nTPM

Brain region

  • cerebellum: 9.2 nTPM
  • white matter: 7.7 nTPM
  • hypothalamus: 7.1 nTPM
  • cerebral cortex: 6.4 nTPM
  • choroid plexus: 6.2 nTPM
  • pons: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0.05
gnomAD missense Z
0.43
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

  • Protein of of unknown function DUF5547
  • Family of unknown function (DUF5547)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2orf15 as an antibody target. Whether an autoantibody or antibody against C2orf15 could matter depends on whether native C2orf15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2orf15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2orf15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C2orf15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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