Seroatlas · Human Serome Atlas

C22orf42

Uncharacterized protein C22orf42

Also known as: CV042_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6IC83
Gene
C22orf42
Ensembl
ENSG00000205856
Chromosome
22
Canonical length
251 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C22orf42 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>Q6IC83|C22orf42
     1  MGSKLTCCLG PSGGLNCDCC RPDVGPCHEC EIPETVAATA PASTTAKPAK LDLKAKKAQL
    61  MQYLSLPKTP KMLKMSKGLD ARSKRWLKII WRRHGIWPLE NIGPTEDVQA SAHGGVEENM
   121  TSDIEIPEAK HDHRPTEDVQ VSAHGGVEEN ITSDIEISEA KHDHHLVEDL SESLSVCLED
   181  FMTSDLSESL SVSLEDFMTS GLSESLSVSL EDLMTPEMAK ERYEDYLCWV KMARSRLNEP
   241  ISSQVLGLLR L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C22orf42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • hypothalamus: 9.4 nTPM
  • pituitary gland: 0.8 nTPM
  • prostate: 0.7 nTPM
  • midbrain: 0.6 nTPM
  • pancreas: 0.3 nTPM

Single-cell type

  • early spermatids: 127 nCPM
  • late spermatids: 47 nCPM
  • late primary spermatocytes: 42 nCPM
  • pancreatic islet cells: 8.3 nCPM
  • other brain neurons: 8.1 nCPM
  • neuroendocrine cells: 3.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 24 nTPM
  • midbrain: 10 nTPM
  • pons: 9.9 nTPM
  • basal ganglia: 4 nTPM
  • thalamus: 3.5 nTPM
  • medulla oblongata: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
gnomAD missense Z
-0.03
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C22orf42 as an antibody target. Whether an autoantibody or antibody against C22orf42 could matter depends on whether native C22orf42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C22orf42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C22orf42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C22orf42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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