C22orf31
Uncharacterized protein C22orf31
Also known as: bK747E2.1, CV031_HUMAN, HS747E2A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95567
- Gene
- C22orf31
- Ensembl
- ENSG00000100249
- Chromosome
- 22
- Canonical length
- 290 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear membrane,Cytosol
OverviewNCBI Gene
No narrative summary is available for C22orf31 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
290 residues, UniProt reviewed canonical sequence.
>O95567|C22orf31
1 MHPINVRRDP SIPIYGLRQS ILLNTRLQDC YVDSPALTNI WMARTCAKQN INAPAPATTS
61 SWEVVRNPLI ASSFSLVKLV LRRQLKNKCC PPPCKFGEGK LSKRLKHKDD SVMKATQQAR
121 KRNFISSKSK QPAGHRRPAG GIRESKESSK EKKLTVRQDL EDRYAEHVAA TQALPQDSGT
181 AAWKGRVLLP ETQKRQQLSE DTLTIHGLPT EGYQALYHAV VEPMLWNPSG TPKRYSLELG
241 KAIKQKLWEA LCSQGAISEG AQRDRFPGRK QPGVHEEPVL KKWPKLKSKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C22orf31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 8.4 nTPM
Expression across tissuesHPA
Tissue
- testis: 8.4 nTPM
- parathyroid gland: 2.9 nTPM
- basal ganglia: 2.6 nTPM
- midbrain: 1.1 nTPM
- hippocampal formation: 1 nTPM
- ovary: 1 nTPM
Single-cell type
- early spermatids: 111 nCPM
- late spermatids: 60 nCPM
- late primary spermatocytes: 24 nCPM
- granulosa cells: 11 nCPM
- retinal pigment epithelial cells: 8.5 nCPM
- müller glia: 7.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 2.6 nTPM
- basal ganglia: 2.5 nTPM
- cerebral cortex: 1.6 nTPM
- hippocampal formation: 1.5 nTPM
- thalamus: 1.2 nTPM
- amygdala: 1.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.49
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.19
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4662
- Domain of unknown function (DUF4662)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C22orf31 as an antibody target. Whether an autoantibody or antibody against C22orf31 could matter depends on whether native C22orf31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C22orf31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C22orf31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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