C22orf23
UPF0193 protein EVG1
Also known as: EVG1, EVG1_HUMAN, FLJ32787, LOC84645
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BZE7
- Gene
- C22orf23
- Ensembl
- ENSG00000128346
- Chromosome
- 22
- Canonical length
- 217 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for C22orf23 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
217 residues, UniProt reviewed canonical sequence.
>Q9BZE7|C22orf23
1 MASQKQMEVV TKGTGFRRRP KTITYTPGTC ELLRVMMKES KLTNIQQRHI MDIMKRGDAL
61 PLQCSPTSSQ RVLPSKQIAS PIYLPPILAA RPHLRPANMC QANGAYSREQ FKPQATRDLE
121 KEKQRLQNIF ATGKDMEERK RKAPPARQKA PAPELDRFEE LVKEIQERKE FLADMEALGQ
181 GKQYRGIILA EISQKLREME DIDHRRSEEL RKGLATTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C22orf23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 88 nTPM
Expression across tissuesHPA
Tissue
- testis: 88 nTPM
- skin: 25 nTPM
- esophagus: 13 nTPM
- fallopian tube: 12 nTPM
- choroid plexus: 11 nTPM
- salivary gland: 9.7 nTPM
Single-cell type
- late primary spermatocytes: 615 nCPM
- late spermatids: 481 nCPM
- early spermatids: 243 nCPM
- early primary spermatocytes: 74 nCPM
- respiratory ciliated cells: 49 nCPM
- epididymal efferent duct ciliated cells: 43 nCPM
Immune cell
- basophil: 0.1 nTPM
- gdT-cell: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 40 nTPM
- medulla oblongata: 36 nTPM
- midbrain: 30 nTPM
- pons: 29 nTPM
- thalamus: 29 nTPM
- cerebellum: 28 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.83
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.31
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Uncharacterised protein family UPF0193
- Uncharacterised protein family (UPF0193)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C22orf23 as an antibody target. Whether an autoantibody or antibody against C22orf23 could matter depends on whether native C22orf23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C22orf23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C22orf23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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