Seroatlas · Human Serome Atlas

C22orf15

Uncharacterized protein C22orf15

Also known as: CV015_HUMAN, FLJ36561, N27C7-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WYQ4
Gene
C22orf15
Ensembl
ENSG00000169314
Chromosome
22
Canonical length
148 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Plasma membrane

OverviewNCBI Gene

No narrative summary is available for C22orf15 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q8WYQ4|C22orf15
     1  MFIKVMFGAG CSVLVNTSCR LVNLTAHLRQ KAGLPPDATI ALLAEDGNLV SLEEDLKEGA
    61  SRAQTMGNSL LKERAIYVLV RIIKGEDMAS TRYESLLENL DDHYPELAEE LRRLSGLSSV
   121  GHNWRKRMGT RRGRHEQSPT SRPRKGPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C22orf15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 17 nTPM
  • testis: 2.8 nTPM
  • lung: 1.7 nTPM
  • choroid plexus: 1.2 nTPM
  • hypothalamus: 1.1 nTPM
  • hippocampal formation: 1 nTPM

Single-cell type

  • respiratory ciliated cells: 114 nCPM
  • fallopian tube ciliated cells: 90 nCPM
  • ependymal cells: 36 nCPM
  • epididymal efferent duct ciliated cells: 30 nCPM
  • endometrial ciliated cells: 23 nCPM
  • late primary spermatocytes: 16 nCPM

Immune cell

  • plasmacytoid DC: 1 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • gdT-cell: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.2 nTPM

Brain region

  • midbrain: 3.6 nTPM
  • medulla oblongata: 2.6 nTPM
  • spinal cord: 2 nTPM
  • pons: 1.6 nTPM
  • hypothalamus: 1.4 nTPM
  • choroid plexus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.65
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C22orf15 as an antibody target. Whether an autoantibody or antibody against C22orf15 could matter depends on whether native C22orf15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C22orf15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C22orf15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C22orf15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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