Seroatlas · Human Serome Atlas

C21orf58

Uncharacterized protein C21orf58

Also known as: CU058_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P58505
Gene: C21orf58
Ensembl: ENSG00000160298
Chromosome: 21
Canonical length: 322 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Primary cilium transition zone

OverviewNCBI Gene

No narrative summary is available for C21orf58 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>P58505|C21orf58
     1  MARSRLPATS LRKPWKLDRQ KLPSPDSGHS LLCGWSPGGK ARPAGNTGAW APAEQFFPAS
    61  NRTREGGGLW PPLPLQSSPA APTMLDSSAA EQVTRLTLKL LGQKLEQERQ NVEGGPEGLH
   121  LEPGNEDRPD DALQTALKRR RDLLQRLREQ HLLDELSRAQ AWSGPSRGAL GSALPPELPP
   181  TGILPTASPS PLAPDPPRII LPTVPQPPAT IIQQLPQQPL IAQIPPPQAF PTQRSGSIKE
   241  DMVELLLLQN AQVHQLVLQN WMLKALPPAL QDPPHVPPRV PRAARPRLPA VHHHHHHHHA
   301  VWPPGAATVL QPAPSLWTPG PP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C21orf58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 25 nTPM
pituitary gland: 21 nTPM
bone marrow: 12 nTPM
thymus: 12 nTPM
testis: 6.8 nTPM
lymph node: 5.9 nTPM

Single-cell type

respiratory ciliated cells: 231 nCPM
fallopian tube ciliated cells: 192 nCPM
endometrial ciliated cells: 158 nCPM
epididymal efferent duct ciliated cells: 140 nCPM
erythrocyte progenitors: 115 nCPM
early primary spermatocytes: 104 nCPM

Immune cell

basophil: 4.4 nTPM
plasmacytoid DC: 1 nTPM
naive B-cell: 0.9 nTPM
naive CD4 T-cell: 0.9 nTPM
T-reg: 0.8 nTPM
naive CD8 T-cell: 0.7 nTPM

Brain region

midbrain: 12 nTPM
white matter: 9 nTPM
choroid plexus: 8.9 nTPM
medulla oblongata: 8.8 nTPM
cerebellum: 7.9 nTPM
thalamus: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C21orf58 as an antibody target. Whether an autoantibody or antibody against C21orf58 could matter depends on whether native C21orf58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C21orf58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C21orf58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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