Seroatlas · Human Serome Atlas

C20orf96

Uncharacterized protein C20orf96

Also known as: CT096_HUMAN, dJ1103G7.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUD7
Gene: C20orf96
Ensembl: ENSG00000196476
Chromosome: 20
Canonical length: 363 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite

OverviewNCBI Gene

No narrative summary is available for C20orf96 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>Q9NUD7|C20orf96
     1  MAHVLQKPKH SGTHSIVQEF QVPDYVPWQQ SKQETKPSTL PPVQQANSLH TSKMKTLTRV
    61  QPVFHFKPTT VVTSCQPKNP RELHRRRKLD PGKMHAKIWL MKTSLRSGRA ALRELRSREN
   121  FLSKLNRELI ETIQEMENST TLHVRALLQQ QDTLATIIDI LEYSNKKRLQ QLKSELQEWE
   181  EKKKCKMSYL EQQAEQLNAK IEKTQEEVNF LSTYMDHEYS IKSVQISTLM RQLQQVKDSQ
   241  QDELDDLGEM RRKVLESLSD KIQKKKKKIL SSVVAETQRP YEEALLQKMW ESQDFLKCMQ
   301  RFREIIDQFE ENMPVLRAEV EELQAQTREP REVIFEDVLL RRPKCTPDMD VILNIPVEEP
   361  LPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C20orf96 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 32 nTPM
testis: 29 nTPM
ovary: 20 nTPM
epididymis: 20 nTPM
choroid plexus: 18 nTPM
cervix: 17 nTPM

Single-cell type

fallopian tube ciliated cells: 227 nCPM
respiratory ciliated cells: 199 nCPM
late primary spermatocytes: 154 nCPM
epididymal efferent duct ciliated cells: 123 nCPM
ependymal cells: 111 nCPM
early spermatids: 102 nCPM

Immune cell

myeloid DC: 3 nTPM
naive B-cell: 1.7 nTPM
memory B-cell: 1.6 nTPM
plasmacytoid DC: 1.4 nTPM
classical monocyte: 1.3 nTPM
NK-cell: 1.3 nTPM

Brain region

midbrain: 30 nTPM
choroid plexus: 28 nTPM
medulla oblongata: 22 nTPM
spinal cord: 20 nTPM
pons: 17 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: -0.51
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4618
Domain of unknown function (DUF4618)

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C20orf96 as an antibody target. Whether an autoantibody or antibody against C20orf96 could matter depends on whether native C20orf96 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C20orf96 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C20orf96 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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