Seroatlas · Human Serome Atlas

C20orf204

Uncharacterized protein C20orf204

Also known as: CT204_HUMAN, DKFZp434G015, FLJ27267, LINC00176, NCRNA00176, PRR17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTL2
Gene
C20orf204
Ensembl
ENSG00000196421
Chromosome
20
Canonical length
189 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C20orf204 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>A0A1B0GTL2|C20orf204
     1  MVPPKPALWA LLLALLGTAP SRAYSPACSV PDVLRHYRAI IFEDLQAAVK WGGAGAEKTR
    61  PGSRHFHFIQ KNLTRPGSSG RRGRPRASCG AQKEHSILLS ISSLGRTLRG AVAGGRRGAL
   121  ERAAWTVAVR TEAVMRRHCR TLRQRSRRPK MRPARRRGGR RQLLLRALDA VATCWEKLFA
   181  LRAPASRDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C20orf204 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 11 nTPM
  • thymus: 1 nTPM
  • basal ganglia: 0.9 nTPM
  • pituitary gland: 0.9 nTPM
  • hypothalamus: 0.8 nTPM
  • small intestine: 0.7 nTPM

Single-cell type

  • innate lymphoid cells: 19 nCPM
  • tuft cells: 12 nCPM
  • lymphatic endothelial cells: 8.6 nCPM
  • thyrotrophs: 6.7 nCPM
  • vascular endothelial cells: 5.6 nCPM
  • brain excitatory neurons: 5.3 nCPM

Immune cell

  • naive CD4 T-cell: 5.9 nTPM
  • naive CD8 T-cell: 4.8 nTPM
  • memory CD4 T-cell: 2.6 nTPM
  • T-reg: 1.5 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • NK-cell: 0.6 nTPM

Brain region

  • cerebellum: 8.3 nTPM
  • pons: 1 nTPM
  • midbrain: 0.7 nTPM
  • cerebral cortex: 0.6 nTPM
  • white matter: 0.6 nTPM
  • amygdala: 0.5 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C20orf204 as an antibody target. Whether an autoantibody or antibody against C20orf204 could matter depends on whether native C20orf204 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C20orf204 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C20orf204 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C20orf204. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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