Seroatlas · Human Serome Atlas

C20orf203

Uncharacterized protein C20orf203

Also known as: CT203_HUMAN, FLJ33706

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBC4
Gene: C20orf203
Ensembl: ENSG00000198547
Chromosome: 20
Canonical length: 194 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is thought to be a human-specific protein. Currently available evidence suggests that orthologous regions in other organisms contain sequence differences that would not support production of a protein product. Genome-wide association studies have suggested the possibility that a SNP in the 3' UTR, rs17123507, could be associated with nicotine addiction. Expression of this gene may be elevated in some individuals with Alzheimer's disease. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>Q8NBC4|C20orf203
     1  MFPRPVLNSR AQAILLPQPP NMLDHRQWPP RLASFPFTKT GMLSRATSVL AGLTAHLWDL
    61  GGGAGRRTSK AQRVHPQPSH QRQPPPPQHP GPYQERIWVG GEGWGEVGGL RLSKVGRRDR
   121  EVGRGLRAPA GRGRAMGGMP RMGTVGDFGQ ALSSLAWTST CFQDFCLPSL PGKLPAPLIS
   181  KQQFLSNSSR SLFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C20orf203 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.77
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 1.7 nTPM
retina: 1.3 nTPM
basal ganglia: 0.9 nTPM
cerebral cortex: 0.9 nTPM
epididymis: 0.8 nTPM
fallopian tube: 0.7 nTPM

Single-cell type

retinal horizontal cells: 2 nCPM
brain inhibitory neurons: 1.1 nCPM
hematopoietic stem cells: 1 nCPM
brain excitatory neurons: 0.7 nCPM
other brain neurons: 0.7 nCPM
retinal amacrine cells: 0.7 nCPM

Immune cell

basophil: 1 nTPM
naive B-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 6.3 nTPM
white matter: 5.8 nTPM
cerebellum: 5.1 nTPM
hypothalamus: 4.9 nTPM
basal ganglia: 4.7 nTPM
medulla oblongata: 4.7 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF5559
Family of unknown function (DUF5559)

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C20orf203 as an antibody target. Whether an autoantibody or antibody against C20orf203 could matter depends on whether native C20orf203 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C20orf203 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C20orf203 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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