C20orf144
Uncharacterized protein C20orf144
Also known as: bclt, CT144_HUMAN, dJ63M2.6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BQM9
- Gene
- C20orf144
- Ensembl
- ENSG00000149609
- Chromosome
- 20
- Canonical length
- 153 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for C20orf144 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
153 residues, UniProt reviewed canonical sequence.
>Q9BQM9|C20orf144
1 MGNYSSHKRT KAPKQARKER PADMDKAWWK SFLNHLTRKK PATRIVLILP LDKRQPLANA
61 GQRIDYASGA GLGSPAAPRL RGAGEGSERE PRMPVLLLLR RQEARRPEEG GARAALSWPR
121 LLSRFRSPGK APREAGPAEE QPRKRCRCPR PQLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C20orf144 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 175 nTPM
Expression across tissuesHPA
Tissue
- testis: 175 nTPM
- breast: 0.1 nTPM
- prostate: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- late spermatids: 3,596 nCPM
- early spermatids: 2,587 nCPM
- late primary spermatocytes: 649 nCPM
- sertoli cells: 13 nCPM
- epicardial cells: 9.1 nCPM
- leydig cells: 7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.76
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Putative Bcl-2 like protein of testis
- Putative Bcl-2 like protein of testis
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C20orf144 as an antibody target. Whether an autoantibody or antibody against C20orf144 could matter depends on whether native C20orf144 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C20orf144 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C20orf144 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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