Seroatlas · Human Serome Atlas

C20orf141

Uncharacterized protein C20orf141

Also known as: CT141_HUMAN, dJ860F19.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NUB4
Gene
C20orf141
Ensembl
ENSG00000258713
Chromosome
20
Canonical length
165 aa
Protein class
Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>Q9NUB4|C20orf141
     1  MTRLCLPRPE AREDPIPVPP RGLGAGEGSG SPVRPPVSTW GPSWAQLLDS VLWLGALGLT
    61  IQAVFSTTGP ALLLLLVSFL TFDLLHRPAG HTLPQRKLLT RGQSQGAGEG PGQQEALLLQ
   121  MGTVSGQLSL QDALLLLLMG LGPLLRACGM PLTLLGLAFC LHPWA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C20orf141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • testis: 124 nTPM
  • retina: 1.5 nTPM
  • endometrium: 0.6 nTPM
  • placenta: 0.5 nTPM
  • adipose tissue: 0.3 nTPM
  • breast: 0.3 nTPM

Single-cell type

  • late spermatids: 4,881 nCPM
  • early spermatids: 1,091 nCPM
  • late primary spermatocytes: 76 nCPM
  • decidual stromal cells: 6.6 nCPM
  • leydig cells: 4.3 nCPM
  • peritubular myoid cells: 4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • thalamus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0.04
gnomAD missense Z
-0.05
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein C20orf141-like
  • Family of unknown function (DUF5562)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C20orf141 as an antibody target. Whether an autoantibody or antibody against C20orf141 could matter depends on whether native C20orf141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C20orf141 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C20orf141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C20orf141. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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