Seroatlas · Human Serome Atlas

C1orf87

Uncharacterized protein C1orf87

Also known as: CA087_HUMAN, CREF, MGC34837

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N0U7
Gene
C1orf87
Ensembl
ENSG00000162598
Chromosome
1
Canonical length
546 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C1orf87 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>Q8N0U7|C1orf87
     1  MSSAWKTPRG SDAMPEIMVK IIGSKHFQYL VEKPKIKEND SLKTETQTMH QKPMTDNARQ
    61  MSRDTPVPIN FTDQQTTDNP DDVKEKKHPE NNQKSENNQK LLTGANSSRF LDGNIPSQAN
   121  VHCSSVPTGD QSLSYVHGIP RRKLRDWSLE QMVRGSSDQP EDIGQSPSGT TNEDAFLLAL
   181  VRRELKSRPL SSNLLEKLQK ELKILDPISS GFLLQSQLSR LFLKHEVPLQ LPTVKILCQR
   241  FSKRGSPEMV NYEKLLWFLN SAASDYPQQN KAAADLRKTE SHGTHSQSTP PQHSSSQPEV
   301  NRSLLEILKM ALRTTNGRLN IDNLNLSFRK EDRSFSGCLP LPKVRAICGK HGLYLTLSLL
   361  ETLLNHQDLG YQNEIKWQNF VEMLTRASSD LLSDLPTGKN EKKAPAPPME PEVPEMSQSK
   421  TEHMKTPEEE LQPESSPAET SACKDPLKPL KIRPVSQPFV NPAVKNKAEE CETWIDRFRK
   481  LENALYLCDL SNTGVLEKER ARRLIHNYNL IYNLSLSPQK IDQALRRFRS GENMLLEPAL
   541  RYLKEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf87 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 28 nTPM
  • choroid plexus: 6.7 nTPM
  • basal ganglia: 5.9 nTPM
  • lung: 3 nTPM
  • hypothalamus: 2.9 nTPM
  • hippocampal formation: 2.6 nTPM

Single-cell type

  • respiratory ciliated cells: 304 nCPM
  • ependymal cells: 263 nCPM
  • fallopian tube ciliated cells: 185 nCPM
  • late primary spermatocytes: 135 nCPM
  • endometrial ciliated cells: 116 nCPM
  • epididymal efferent duct ciliated cells: 95 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 18 nTPM
  • medulla oblongata: 18 nTPM
  • spinal cord: 12 nTPM
  • pons: 6.2 nTPM
  • choroid plexus: 6 nTPM
  • white matter: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0
gnomAD missense Z
-0.21
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • EF-hand domain pair
  • Protein of unknown function DUF5580
  • DUF5580, N-terminal domain
  • DUF5580, middle domain
  • DUF5580, C-terminal domain
  • Family of unknown function (DUF5580) N-terminal domain
  • Family of unknown function (DUF5580) middle domain
  • Family of unknown function (DUF5580) C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf87 as an antibody target. Whether an autoantibody or antibody against C1orf87 could matter depends on whether native C1orf87 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf87 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf87 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf87. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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