C1orf74
UPF0739 protein C1orf74
Also known as: CA074_HUMAN, FLJ25078, URLC4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96LT6
- Gene
- C1orf74
- Ensembl
- ENSG00000162757
- Chromosome
- 1
- Canonical length
- 269 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
No narrative summary is available for C1orf74 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
269 residues, UniProt reviewed canonical sequence.
>Q96LT6|C1orf74
1 MLLLDLMSSP SPQLLVAAAQ QTLGMGKRRS PPQAICLHLA GEVLAVARGL KPAVLYDCNC
61 AGASELQSYL EELKGLGFLT FGLHILEIGE NSLIVSPEHV CQHLEQVLLG TIAFVDVSSC
121 QRHPSVCSLD QLQDLKALVA EIITHLQGLQ RDLSLAVSYS RLHSSDWNLC TVFGILLGYP
181 VPYTFHLNQG DDNCLALTPL RVFTARISWL LGQPPILLYS FSVPESLFPG LRDILNTWEK
241 DLRTRFRTQN DFADLSISSE IVTLPAVALLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C1orf74 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 6.4 nTPM
Expression across tissuesHPA
Tissue
- skin: 6.4 nTPM
- spleen: 4 nTPM
- lymph node: 3.9 nTPM
- esophagus: 3.8 nTPM
- small intestine: 2.6 nTPM
- cerebellum: 2 nTPM
Single-cell type
- endometrial luminal cells: 9.8 nCPM
- epididymal basal cells: 6.8 nCPM
- esophageal suprabasal cells: 5.2 nCPM
- oocytes: 4.6 nCPM
- endometrial glandular cells: 4.4 nCPM
- urothelial cells: 4.3 nCPM
Immune cell
- basophil: 4.7 nTPM
- naive B-cell: 3.6 nTPM
- plasmacytoid DC: 2.6 nTPM
- memory B-cell: 1.8 nTPM
- myeloid DC: 1.4 nTPM
- NK-cell: 1.4 nTPM
Brain region
- cerebellum: 2.7 nTPM
- hypothalamus: 2.6 nTPM
- white matter: 2.2 nTPM
- medulla oblongata: 2.1 nTPM
- pons: 2.1 nTPM
- spinal cord: 2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.1
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.74
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4504
- Domain of unknown function (DUF4504)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C1orf74 as an antibody target. Whether an autoantibody or antibody against C1orf74 could matter depends on whether native C1orf74 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C1orf74 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C1orf74 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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