Seroatlas · Human Serome Atlas

C1orf54

Uncharacterized protein C1orf54

Also known as: CA054_HUMAN, FLJ23221

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWF1
Gene: C1orf54
Ensembl: ENSG00000118292
Chromosome: 1
Canonical length: 131 aa
Protein class: Predicted secreted proteins
Subcellular location: Plasma membrane
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to act upstream of or within epithelial cell proliferation involved in renal tubule morphogenesis; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to wounding. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>Q8WWF1|C1orf54
     1  MDVLFVAIFA VPLILGQEYE DEERLGEDEY YQVVYYYTVT PSYDDFSADF TIDYSIFESE
    61  DRLNRLDKDI TEAIETTISL ETARADHPKP VTVKPVTTEP SPDLNDAVSS LRSPIPLLLS
   121  CAFVQVGMYF M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 74 nTPM
seminal vesicle: 71 nTPM
spleen: 65 nTPM
choroid plexus: 60 nTPM
lymph node: 59 nTPM
smooth muscle: 56 nTPM

Single-cell type

kupffer cells: 325 nCPM
cdc: 211 nCPM
peritubular myoid cells: 129 nCPM
leydig cells: 106 nCPM
vascular smooth muscle cells: 79 nCPM
macrophages: 77 nCPM

Immune cell

myeloid DC: 104 nTPM
classical monocyte: 21 nTPM
intermediate monocyte: 21 nTPM
total PBMC: 6.4 nTPM
non-classical monocyte: 5.7 nTPM
memory CD4 T-cell: 3.8 nTPM

Brain region

thalamus: 31 nTPM
spinal cord: 29 nTPM
white matter: 27 nTPM
hypothalamus: 26 nTPM
medulla oblongata: 26 nTPM
cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4634
Domain of unknown function (DUF4634)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf54 as an antibody target. Whether an autoantibody or antibody against C1orf54 could matter depends on whether native C1orf54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf54 is annotated as secreted, so native C1orf54 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1orf54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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