Seroatlas · Human Serome Atlas

C1orf53

Uncharacterized protein C1orf53

Also known as: CA053_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VUE5
Gene
C1orf53
Ensembl
ENSG00000203724
Chromosome
1
Canonical length
145 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Aggresome

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q5VUE5|C1orf53
     1  MAARQIWART GAALCRQPSA APPPAPLWVR AGFRQQLSLT LCPANEGNCG GSAPSTPGRP
    61  ERAARPSVSE ELTAAERQIA ELHAAACAAG QLNYVDPATG YVVLTQIAHL QRGECCGSAC
   121  RHCPYGQVNV KDPSKKKQFN SYFYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • liver: 15 nTPM
  • adrenal gland: 9.4 nTPM
  • heart muscle: 6.7 nTPM
  • amygdala: 6 nTPM
  • kidney: 5.3 nTPM
  • choroid plexus: 5.1 nTPM

Single-cell type

  • hepatocytes: 73 nCPM
  • oocytes: 65 nCPM
  • epididymal clear cells: 33 nCPM
  • conjunctival goblet cells: 27 nCPM
  • esophageal suprabasal cells: 26 nCPM
  • alveolar cells type 2: 25 nCPM

Immune cell

  • intermediate monocyte: 9 nTPM
  • non-classical monocyte: 4.4 nTPM
  • classical monocyte: 2.7 nTPM
  • myeloid DC: 2.1 nTPM
  • total PBMC: 0.9 nTPM
  • memory CD8 T-cell: 0.6 nTPM

Brain region

  • choroid plexus: 9.1 nTPM
  • thalamus: 4.8 nTPM
  • hippocampal formation: 3.5 nTPM
  • amygdala: 3.2 nTPM
  • midbrain: 3.2 nTPM
  • white matter: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF5522
  • Family of unknown function (DUF5522)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf53 as an antibody target. Whether an autoantibody or antibody against C1orf53 could matter depends on whether native C1orf53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf53 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf53. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...