Seroatlas · Human Serome Atlas

C1orf52

UPF0690 protein C1orf52

Also known as: CA052_HUMAN, FLJ44982, gm117

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6N3
Gene: C1orf52
Ensembl: ENSG00000162642
Chromosome: 1
Canonical length: 182 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q8N6N3|C1orf52
     1  MAAEEKDPLS YFAAYGSSSS GSSDEEDNIE PEETSRRTPD PAKSAGGCRN KAEKRLPGPD
    61  ELFRSVTRPA FLYNPLNKQI DWERHVVKAP EEPPKEFKIW KSNYVPPPET YTTEKKPPPP
   121  ELDMAIKWSN IYEDNGDDAP QNAKKARLLP EGEETLESDD EKDEHTSKKR KVEPGEPAKK
   181  KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 22 nTPM
skeletal muscle: 15 nTPM
lymph node: 14 nTPM
basal ganglia: 14 nTPM
cerebral cortex: 13 nTPM
placenta: 11 nTPM

Single-cell type

late primary spermatocytes: 127 nCPM
basal keratinocytes: 115 nCPM
suprabasal keratinocytes: 101 nCPM
early primary spermatocytes: 86 nCPM
extravillous trophoblasts: 82 nCPM
syncytiotrophoblasts: 77 nCPM

Immune cell

memory B-cell: 36 nTPM
neutrophil: 30 nTPM
eosinophil: 30 nTPM
intermediate monocyte: 29 nTPM
naive CD4 T-cell: 28 nTPM
plasmacytoid DC: 27 nTPM

Brain region

hippocampal formation: 43 nTPM
cerebral cortex: 40 nTPM
white matter: 39 nTPM
basal ganglia: 37 nTPM
midbrain: 31 nTPM
thalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0.05
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4660
Domain of unknown function (DUF4660)

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf52 as an antibody target. Whether an autoantibody or antibody against C1orf52 could matter depends on whether native C1orf52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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